DDX42
| DEAD (Asp-Glu-Ala-Asp) box helicase 42 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | DDX42 ; DDX42P; RHELP; RNAHP; SF3B8; SF3b125 | ||||||||||||
| External IDs | OMIM: 613369 MGI: 1919297 HomoloGene: 49137 GeneCards: DDX42 Gene | ||||||||||||
| EC number | 3.6.4.13 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11325 | 72047 | |||||||||||
| Ensembl | ENSG00000198231 | ENSMUSG00000020705 | |||||||||||
| UniProt | Q86XP3 | Q810A7 | |||||||||||
| RefSeq (mRNA) | NM_007372 | NM_028074 | |||||||||||
| RefSeq (protein) | NP_031398 | NP_082350 | |||||||||||
| Location (UCSC) | Chr 17: 61.85 – 61.9 Mb | Chr 11: 106.22 – 106.25 Mb | |||||||||||
| PubMed search | |||||||||||||
ATP-dependent RNA helicase DDX42 is an enzyme that in humans is encoded by the DDX42 gene.[1][2]
Function
This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.[2]
Interactions
DDX42 has been shown to interact with SF3B1.[3]
References
- ↑ Suk K, Kim S, Kim YH, Oh SH, Lee MK, Kim KW et al. (Jun 2000). "Identification of a novel human member of the DEAD box protein family". Biochim. Biophys. Acta 1501 (1): 63–9. doi:10.1016/S0925-4439(00)00010-7. PMID 10727850.
- ↑ 2.0 2.1 "Entrez Gene: DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42".
- ↑ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937. Vancouver style error (help)
Further reading
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Uhlmann-Schiffler H, Jalal C, Stahl H (2006). "Ddx42p--a human DEAD box protein with RNA chaperone activities". Nucleic Acids Res. 34 (1): 10–22. doi:10.1093/nar/gkj403. PMC 1325199. PMID 16397294.
- Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. Vancouver style error (help)
- Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937. Vancouver style error (help)