DDEF1
| ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | |||||||||||||
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 PDB rendering based on 2da0. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ASAP1 ; AMAP1; CENTB4; DDEF1; PAG2; PAP; ZG14P | ||||||||||||
| External IDs | OMIM: 605953 MGI: 1342335 HomoloGene: 7684 GeneCards: ASAP1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 50807 | 13196 | |||||||||||
| Ensembl | ENSG00000153317 | ENSMUSG00000022377 | |||||||||||
| UniProt | Q9ULH1 | Q9QWY8 | |||||||||||
| RefSeq (mRNA) | NM_001247996 | NM_001276461 | |||||||||||
| RefSeq (protein) | NP_001234925 | NP_001263390 | |||||||||||
| Location (UCSC) | Chr 8: 131.06 – 131.46 Mb | Chr 15: 64.09 – 64.38 Mb | |||||||||||
| PubMed search | |||||||||||||
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ASAP1 gene.[1][2]
Interactions
DDEF1 has been shown to interact with Src.[3]
References
- ↑ Brown MT, Andrade J, Radhakrishna H, Donaldson JG, Cooper JA, Randazzo PA (Dec 1998). "ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src". Mol Cell Biol 18 (12): 7038–51. PMC 109286. PMID 9819391.
- ↑ "Entrez Gene: DDEF1 development and differentiation enhancing factor 1".
- ↑ Brown, M T; Andrade J; Radhakrishna H; Donaldson J G; Cooper J A; Randazzo P A (Dec 1998). "ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src". Mol. Cell. Biol. (UNITED STATES) 18 (12): 7038–51. ISSN 0270-7306. PMC 109286. PMID 9819391.
Further reading
- Nagase T, Ishikawa K, Kikuno R et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
- Furman C, Short SM, Subramanian RR et al. (2002). "DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.". J. Biol. Chem. 277 (10): 7962–9. doi:10.1074/jbc.M109149200. PMID 11773070.
- Scott MP, Zappacosta F, Kim EY et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
- Liu Y, Loijens JC, Martin KH et al. (2002). "The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly.". Mol. Biol. Cell 13 (6): 2147–56. doi:10.1091/mbc.E02-01-0018. PMC 117631. PMID 12058076.
- Oshiro T, Koyama S, Sugiyama S et al. (2002). "Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.". J. Biol. Chem. 277 (41): 38618–26. doi:10.1074/jbc.M203453200. PMID 12149250.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Oda A, Wada I, Miura K et al. (2003). "CrkL directs ASAP1 to peripheral focal adhesions.". J. Biol. Chem. 278 (8): 6456–60. doi:10.1074/jbc.M210817200. PMID 12522101.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Onodera Y, Hashimoto S, Hashimoto A et al. (2005). "Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.". EMBO J. 24 (5): 963–73. doi:10.1038/sj.emboj.7600588. PMC 554134. PMID 15719014.
- Ehlers JP, Worley L, Onken MD, Harbour JW (2005). "DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma.". Clin. Cancer Res. 11 (10): 3609–13. doi:10.1158/1078-0432.CCR-04-1941. PMID 15897555.
- Che MM, Boja ES, Yoon HY et al. (2005). "Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains.". Cell. Signal. 17 (10): 1276–88. doi:10.1016/j.cellsig.2005.01.007. PMID 16038802.
- Nusbaum C, Mikkelsen TS, Zody MC et al. (2006). "DNA sequence and analysis of human chromosome 8.". Nature 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
- Hashimoto S, Hirose M, Hashimoto A et al. (2006). "Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.". Proc. Natl. Acad. Sci. U.S.A. 103 (18): 7036–41. doi:10.1073/pnas.0509166103. PMC 1459014. PMID 16636290.
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