DBR1
| Debranching RNA lariats 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbol | DBR1 | ||||||||||||
| External IDs | OMIM: 607024 MGI: 1931520 HomoloGene: 9428 GeneCards: DBR1 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 51163 | 83703 | |||||||||||
| Ensembl | ENSG00000138231 | ENSMUSG00000032469 | |||||||||||
| UniProt | Q9UK59 | Q923B1 | |||||||||||
| RefSeq (mRNA) | NM_016216 | NM_031403 | |||||||||||
| RefSeq (protein) | NP_057300 | NP_113580 | |||||||||||
| Location (UCSC) | Chr 3: 137.88 – 137.89 Mb | Chr 9: 99.58 – 99.58 Mb | |||||||||||
| PubMed search | |||||||||||||
Lariat debranching enzyme is a protein that in humans is encoded by the DBR1 gene.[1][2]
The RNA lariat debranching enzyme, or DBR1, specifically hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules.[supplied by OMIM][2]
References
- ↑ Kim JW, Kim HC, Kim GM, Yang JM, Boeke JD, Nam K (Sep 2000). "Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants". Nucleic Acids Res 28 (18): 3666–73. doi:10.1093/nar/28.18.3666. PMC 110720. PMID 10982890.
- ↑ 2.0 2.1 "Entrez Gene: DBR1 debranching enzyme homolog 1 (S. cerevisiae)".
Further reading
- Chapman KB, Boeke JD (1991). "Isolation and characterization of the gene encoding yeast debranching enzyme.". Cell 65 (3): 483–92. doi:10.1016/0092-8674(91)90466-C. PMID 1850323.
- Arenas J, Hurwitz J (1987). "Purification of a RNA debranching activity from HeLa cells.". J. Biol. Chem. 262 (9): 4274–9. PMID 2435736.
- Martin A, Schneider S, Schwer B (2002). "Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome.". J. Biol. Chem. 277 (20): 17743–50. doi:10.1074/jbc.M200762200. PMID 11886864.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ye Y, De Leon J, Yokoyama N et al. (2006). "DBR1 siRNA inhibition of HIV-1 replication.". Retrovirology 2: 63. doi:10.1186/1742-4690-2-63. PMC 1266399. PMID 16232320.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.