DAPK3

Death-associated protein kinase 3

PDB rendering based on 1yrp.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1YRP, 2J90, 3BHY, 3BQR

Identifiers

Symbols

DAPK3 ; DLK; ZIP; ZIPK

External IDs

OMIM: 603289 MGI: 1203520 HomoloGene: 20353 IUPHAR: 2004 ChEMBL: 2468 GeneCards: DAPK3 Gene

EC number

2.7.11.1

Gene ontology
Molecular function	• protein serine/threonine kinase activity • calmodulin-dependent protein kinase activity • ATP binding • identical protein binding • protein homodimerization activity • leucine zipper domain binding
Cellular component	• chromosome, centromeric region • nucleus • cytoplasm • microtubule organizing center • PML body
Biological process	• cytokinesis • transcription, DNA-templated • regulation of transcription, DNA-templated • protein phosphorylation • apoptotic process • regulation of smooth muscle contraction • regulation of mitosis • regulation of autophagy • chromatin modification • negative regulation of translation • neuron differentiation • intracellular signal transduction • regulation of apoptotic process • protein autophosphorylation • cellular response to interferon-gamma • positive regulation of canonical Wnt signaling pathway • apoptotic signaling pathway • regulation of cell motility • regulation of actin cytoskeleton reorganization • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
3.96 – 3.97 Mb

Chr 10:
81.18 – 81.19 Mb

PubMed search

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene.^[1]^[2]

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.^[2]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.^[3]

Interactions

DAPK3 has been shown to interact with PAWR^[4] and Death associated protein 6.^[4]

References

↑ Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Mol Cell Biol 18 (3): 1642–51. PMC 108879. PMID 9488481.
↑ 2.0 2.1 "Entrez Gene: DAPK3 death-associated protein kinase 3".
↑ Shoval Y, Pietrokovski S, Kimchi A (October 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLoS Genet. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
↑ 4.0 4.1 Kawai T, Akira S, Reed JC (September 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Mol. Cell. Biol. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.

Saito T, Seki N, Ohira M et al. (1998). "Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization.". J. Hum. Genet. 43 (3): 209–11. doi:10.1007/s100380050073. PMID 9747039.
Murata-Hori M, Suizu F, Iwasaki T et al. (1999). "ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells.". FEBS Lett. 451 (1): 81–4. doi:10.1016/S0014-5793(99)00550-5. PMID 10356987.
Page G, Lödige I, Kögel D, Scheidtmann KH (2000). "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis.". FEBS Lett. 462 (1-2): 187–91. doi:10.1016/S0014-5793(99)01529-X. PMID 10580117.
Page G, Kögel D, Rangnekar V, Scheidtmann KH (2000). "Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis.". Oncogene 18 (51): 7265–73. doi:10.1038/sj.onc.1203170. PMID 10602480.
Cariou B, Perdereau D, Cailliau K et al. (2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta.". Mol. Cell. Biol. 22 (20): 6959–70. doi:10.1128/MCB.22.20.6959-6970.2002. PMC 139806. PMID 12242277.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Preuss U, Landsberg G, Scheidtmann KH (2003). "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase.". Nucleic Acids Res. 31 (3): 878–85. doi:10.1093/nar/gkg176. PMC 149197. PMID 12560483.
Kawai T, Akira S, Reed JC (2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.". Mol. Cell. Biol. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Burch LR, Scott M, Pohler E et al. (2004). "Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1.". J. Mol. Biol. 337 (1): 115–28. doi:10.1016/j.jmb.2003.10.081. PMID 15001356.
Endo A, Surks HK, Mochizuki S et al. (2004). "Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase.". J. Biol. Chem. 279 (40): 42055–61. doi:10.1074/jbc.M403676200. PMID 15292222.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Schaaf CP, Benzing J, Schmitt T et al. (2005). "Novel interaction partners of the TPR/MET tyrosine kinase.". FASEB J. 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961.
Yu H, Jiang D, Guo Z et al. (2005). "TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3.". Int. J. Androl. 28 (3): 163–70. doi:10.1111/j.1365-2605.2005.00522.x. PMID 15910542.
Shoval Y, Pietrokovski S, Kimchi A. (2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene.". PLoS Genet. 3 (10): 1884–93. doi:10.1371/journal.pgen.0030180. PMC 2041995. PMID 17953487.
Takamoto N, Komatsu S, Komaba S et al. (2007). "Novel ZIP kinase isoform lacks leucine zipper.". Arch. Biochem. Biophys. 456 (2): 194–203. doi:10.1016/j.abb.2006.09.026. PMC 2758612. PMID 17126281.

PDB gallery

1yrp: Catalytic domain of human ZIP kinase phosphorylated at Thr265

2j90: CRYSTAL STRUCTURE OF HUMAN ZIP KINASE IN COMPLEX WITH A TETRACYCLIC PYRIDONE INHIBITOR (PYRIDONE 6)

Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated Mammalian target of rapamycin EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1

Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3

Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3

(3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)) (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB

(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G

(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4

Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase

Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10

Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-

IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP

cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY

cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1

Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3

Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase

Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2

G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6

Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1

Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4

Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2

Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDC2L5 CRKRS PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1

(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1

Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14

MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14

Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3

(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-

Tropomyosin kinase (EC 2.7.11.28)	-

Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-

Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

Biochemistry overview
Enzymes overview
By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
2.1
- 2
- 3
- 4
- 5
- 6
- 7
  - 2.7.10
  - 11-12
- 8
3.1
- - 3.1.3.48
- 2
- 3
- 4
  - 3.4.21
  - 22
  - 23
  - 24
- 5
- 6
- 7
4.1
- 2
- 3
- 4
- 5
- 6
5.1
- 2
- 3
- 4
- 99
6.1-3
- 4
- 5-6

DAPK3

Function

Interactions

References

Further reading