DAB2

Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
PDB rendering based on 1m7e.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2LSW
Identifiers
Symbols	DAB2 ; DOC-2; DOC2
External IDs	OMIM: 601236 MGI: 109175 HomoloGene: 1026 GeneCards: DAB2 Gene
Gene ontology Molecular function • integrin binding • protein binding • phosphatidylinositol-4,5-bisphosphate binding • protein C-terminus binding • AP-2 adaptor complex binding • clathrin adaptor activity • cargo receptor activity • SMAD binding Cellular component • nucleolus • lysosomal membrane • plasma membrane • coated pit • apical plasma membrane • clathrin coat of coated pit • clathrin-coated vesicle membrane • intracellular membrane-bounded organelle • transforming growth factor beta receptor homodimeric complex • extracellular vesicular exosome Biological process • cell morphogenesis involved in differentiation • in utero embryonic development • positive regulation of receptor recycling • positive regulation of protein phosphorylation • receptor-mediated endocytosis • pinocytosis • apoptotic process • activation of JUN kinase activity • endoderm development • excretion • cell proliferation • positive regulation of epithelial to mesenchymal transition • positive regulation of pathway-restricted SMAD protein phosphorylation • protein transport • Wnt signaling pathway • myeloid cell differentiation • positive regulation of cell migration • positive regulation of transforming growth factor beta receptor signaling pathway • negative regulation of protein binding • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • positive regulation of transcription elongation from RNA polymerase II promoter • negative regulation of apoptotic process • positive regulation of endocytosis • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • clathrin coat assembly • positive regulation of SMAD protein import into nucleus • negative regulation of androgen receptor signaling pathway • membrane organization • cellular response to transforming growth factor beta stimulus • negative regulation of canonical Wnt signaling pathway • positive regulation of substrate adhesion-dependent cell spreading • positive regulation of Wnt signaling pathway, planar cell polarity pathway • positive regulation of clathrin-mediated endocytosis • positive regulation of early endosome to late endosome transport • positive regulation of integrin-mediated signaling pathway • negative regulation of extrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1601	13132
Ensembl	ENSG00000153071	ENSMUSG00000022150
UniProt	P98082	P98078
RefSeq (mRNA)	NM_001244871	NM_001008702
RefSeq (protein)	NP_001231800	NP_001008702
Location (UCSC)	Chr 5: 39.37 – 39.46 Mb	Chr 15: 6.3 – 6.44 Mb
PubMed search

Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.^[1][2]

Function

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).^[3]

Interactions

DAB2 has been shown to interact with:

References

Further reading

PDB gallery 1m7e: Crystal structure of the phosphotyrosine binding domain(PTB) of mouse Disabled 2(Dab2):implications for Reeling signaling  1p3r: Crystal structure of the phosphotyrosin binding domain(PTB) of mouse Disabled 1(Dab1)