Cyclin K
Cyclin-K is a protein that in humans is encoded by the CCNK gene.[1][2][3]
Function
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.[3]
Interactions
Cyclin K has been shown to interact with CDK9.[2]
References
- ↑ Edwards MC, Wong C, Elledge SJ (Jul 1998). "Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity". Molecular and Cellular Biology 18 (7): 4291–300. PMC 109013. PMID 9632813.
- ↑ 2.0 2.1 Fu TJ, Peng J, Lee G, Price DH, Flores O (Dec 1999). "Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription". The Journal of Biological Chemistry 274 (49): 34527–30. doi:10.1074/jbc.274.49.34527. PMID 10574912.
- ↑ 3.0 3.1 "Entrez Gene: CCNK cyclin K".
Further reading
- Lin X, Taube R, Fujinaga K, Peterlin BM (May 2002). "P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA". The Journal of Biological Chemistry 277 (19): 16873–8. doi:10.1074/jbc.M200117200. PMID 11884399.
- Mori T, Anazawa Y, Matsui K, Fukuda S, Nakamura Y, Arakawa H (2002). "Cyclin K as a direct transcriptional target of the p53 tumor suppressor". Neoplasia 4 (3): 268–74. doi:10.1038/sj/neo/7900235. PMC 1531701. PMID 11988847.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J et al. (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. Vancouver style error (help)
- Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. Vancouver style error (help)
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P et al. (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Baek K, Brown RS, Birrane G, Ladias JA (Feb 2007). "Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9". Journal of Molecular Biology 366 (2): 563–73. doi:10.1016/j.jmb.2006.11.057. PMC 1852425. PMID 17169370.
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