Cyclin B2
Cyclin B2 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||||
Symbols | CCNB2 ; HsT17299 | ||||||||||||
External IDs | OMIM: 602755 MGI: 88311 HomoloGene: 74359 ChEMBL: 3723 GeneCards: CCNB2 Gene | ||||||||||||
| |||||||||||||
RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 9133 | 12442 | |||||||||||
Ensembl | ENSG00000157456 | ENSMUSG00000032218 | |||||||||||
UniProt | O95067 | P30276 | |||||||||||
RefSeq (mRNA) | NM_004701 | NM_007630 | |||||||||||
RefSeq (protein) | NP_004692 | NP_031656 | |||||||||||
Location (UCSC) | Chr 15: 59.11 – 59.13 Mb | Chr 9: 70.41 – 70.42 Mb | |||||||||||
PubMed search | |||||||||||||
G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.
Function
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.[1]
Interactions
Cyclin B2 has been shown to interact with TGF beta receptor 2.[2]
See also
References
- ↑ "Entrez Gene: CCNB2 cyclin B2".
- ↑ Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY (Jan 1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene 18 (1): 269–75. doi:10.1038/sj.onc.1202263. PMID 9926943.
Further reading
- He J, Choe S, Walker R, Di Marzio P, Morgan DO, Landau NR (1995). "Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity". J. Virol. 69 (11): 6705–11. PMC 189580. PMID 7474080.
- Re F, Braaten D, Franke EK, Luban J (1995). "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B". J. Virol. 69 (11): 6859–64. PMC 189600. PMID 7474100.
- Di Marzio P, Choe S, Ebright M, Knoblauch R, Landau NR (1995). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr". J. Virol. 69 (12): 7909–16. PMC 189735. PMID 7494303.
- Jowett JB, Planelles V, Poon B, Shah NP, Chen ML, Chen IS (1995). "The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle". J. Virol. 69 (10): 6304–13. PMC 189529. PMID 7666531.
- Jackman M, Firth M, Pines J (1995). "Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus". EMBO J. 14 (8): 1646–54. PMC 398257. PMID 7737117.
- Pines J, Hunter T (1994). "The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B". EMBO J. 13 (16): 3772–81. PMC 395290. PMID 8070405.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Poon B, Jowett JB, Stewart SA, Armstrong RW, Rishton GM, Chen IS (1997). "Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard". J. Virol. 71 (5): 3961–71. PMC 191548. PMID 9094673.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Mahalingam S, Ayyavoo V, Patel M, Kieber-Emmons T, Kao GD, Muschel RJ et al. (1998). "HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3419–24. doi:10.1073/pnas.95.7.3419. PMC 19851. PMID 9520381.
- Brandeis M, Rosewell I, Carrington M, Crompton T, Jacobs MA, Kirk J et al. (1998). "Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4344–9. doi:10.1073/pnas.95.8.4344. PMC 22491. PMID 9539739.
- Felzien LK, Woffendin C, Hottiger MO, Subbramanian RA, Cohen EA, Nabel GJ (1998). "HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5281–6. doi:10.1073/pnas.95.9.5281. PMC 20252. PMID 9560267.
- Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY (1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene 18 (1): 269–75. doi:10.1038/sj.onc.1202263. PMID 9926943.
- Elder RT, Yu M, Chen M, Edelson S, Zhao Y (2000). "Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint". Virus Res. 68 (2): 161–73. doi:10.1016/S0168-1702(00)00167-2. PMID 10958988.
- Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
- Mouland AJ, Coady M, Yao XJ, Cohen EA (2002). "Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression". Virology 292 (2): 321–30. doi:10.1006/viro.2001.1261. PMID 11878934.
|