Cyanodothiepin

Cyanodothiepin
Systematic (IUPAC) name
11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]thiepine-2-carbonitrile
Clinical data
Identifiers
90667-37-1
None
ChemSpider 30780728
Chemical data
Formula C20H20N2S
320.45 g/mol

Cyanodothiepin (BTS-56,424) is a drug of the tricyclic antidepressant (TCA) family which is a potent and highly selective (over norepinephrine and dopamine uptake) inhibitor of the reuptake of serotonin.[1][2][3] It also has moderate affinity for the mACh receptors and weak/negligible affinity for the α1-adrenergic, 5-HT2A, D1, and D2 receptors;[1][2][3] the H1 receptor has not been assayed,[3] but cyanodothiepin is less sedating than the related drug cianopramine, suggesting its antihistamine activity is not as pronounced as other TCAs.[1][3] Cyanodothiepin is active in the forced swimming test (FST), inferring that it may possess antidepressant properties in humans. However, it is only weakly active compared to cianopramine and imipramine in monoamine depletion-based tests of antidepressant potential.[1]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Luscombe, G. P.; Buckett, W. R. (1993). "Pharmacology of Cyanodothiepin (BTS 56 424), a Selective 5-Hydroxytryptamine Reuptake Inhibitor". Drug Development Research 29 (3): 235–248. doi:10.1002/ddr.430290311.
  2. ↑ 2.0 2.1 Jucker , E. (2000). Progress in Drug Research. Birkhäuser. pp. 79–80. ISBN 978-3-7643-6113-6. Retrieved 2011-11-25.
  3. ↑ 3.0 3.1 3.2 3.3 Olivier, B.; van Wijngaarden, I.; Soudijn, W. (1997). Serotonin Receptors and their Ligands. Elsevier. p. 332. ISBN 978-0-444-82041-9. Retrieved 2011-11-25.