Cunninghamella
| Cunninghamella | |
|---|---|
 | |
| Cunninghamella echinulata | |
Scientific classification  | |
| Kingdom: | Fungi |
| Order: | Mucorales |
| Family: | Cunninghamellaceae |
| Genus: | Cunninghamella Matruchot, 1903 |
| Type species | |
| Cunninghamella africana Matr. (1903) | |
Cunninghamella is a genus of fungus in the Mucorales order, and the family Cunninghamellaceae.[1]
It can grow on Sabouraud's agar.[2]
Species
The genus Cunninghamella contains 16 species:[3]
- C. africana
- C. bainieri
- C. bertholletiae
- C. binarieae
- C. blakesleeana
- C. clavata
- C. echinulata
- C. elegans
- C. homothallica
- C. intermedia
- C. japonica
- C. multiverticillata
- C. phaeospora
- C. polymorpha
- C. septata
- C. A18
- C. CL023
- C. vesiculosa
Synonyms for other species
- Cunninghamella meineckella, a synonym for Spiniger meineckellus, a plant pathogen
- Cunninghamella mandshurica, a synonym for Choanephora cucurbitarum, a plant pathogen that causes fruit rot in cucurbit
Use in the investigation of drug and xenobiotics metabolism
Members of this genus are often used in studies investigating the metabolism of drugs, because these species metabolize a wide range of drugs in manners similar to mammalian enzyme systems.[4] Many species are also capable of oxidizing polycyclic aromatic hydrocarbons, a class of stable organic molecules that tends to persist in the environment and contains many known carcinogenic and mutagenic compounds.[5]
The presence of a cytochrome P-450 has been demonstrated in C. bainieri.[6]
See also
References
- ↑ Cunninghamella at the US National Library of Medicine Medical Subject Headings (MeSH)
- ↑ "Mycology Online -- Cunninghamella". Retrieved 2008-12-10.
- ↑ "Cunninghamella". Retrieved 2009-03-17.
- ↑ Asha S, Vidyavathi M (2009). "Cunninghamella--a microbial model for drug metabolism studies--a review". Biotechnol. Adv. 27 (1): 16–29. doi:10.1016/j.biotechadv.2008.07.005. PMID 18775773. Retrieved 2009-03-17.
- ↑ Cerniglia, Carl E. (1992). "Biodegradation of polycyclic aromatic hydrocarbons". Biodegradation 3 (2–3): 351–368. doi:10.1007/BF00129093.
- ↑ Aryl hydrocarbon hydroxylase activity in the fungus Cunninghamella bainieri: Evidence for the presence of cytochrome P-450. J.P. Ferris, L.H. MacDonald, M.A. Patrie and M.A. Martin, Archives of Biochemistry and Biophysics, Volume 175, Issue 2, August 1976, pages 443-452, doi:10.1016/0003-9861(76)90532-4
External links
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