Craig plot
The Craig plot, named after Paul N. Craig, is a plot of two substituent parameters (e.g. Hansch-Fujita π constant and sigma constant) used in rational drug design.[1]
Two most used forms of a Craig plot are
- plotting the sigma constants of the Hammett equation versus hydrophobicity
- plotting the steric terms of the Taft equation against hydrophobicity
See also
- Quantitative structure-activity relationship
- pKa
References
1. P.N. Craig, J.Med.Chem., 14, 680-684 (1971).[1]