Coronavirus 3' UTR pseudoknot
| Coronavirus 3' UTR pseudoknot | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of Corona_pk3 | |
| Identifiers | |
| Symbol | Corona_pk3 |
| Rfam | RF00165 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| SO | 0000205 |
The Coronavirus 3' UTR pseudoknot is an RNA structure found in the coronavirus genome. Coronaviruses contain 30 kb single-stranded positive-sense RNA genomes. The 3' UTR region of these coronavirus genomes contains a conserved ~55 nucleotide pseudoknot structure which is necessary for viral genome replication.[1] The mechanism of cis-regulation is unclear, but this element is postulated to function in the plus-strand.
Other RNA families identified in the coronavirus include the coronavirus SL-III cis-acting replication element (CRE), the coronavirus frameshifting stimulation element, the coronavirus 3' stem-loop II-like motif (s2m) and the coronavirus packaging signal.
References
- ↑ Williams, GD; Chang RY; Brian DA (1999). "A phylogenetically conserved hairpin-type 3' untranslated region pseudoknot functions in coronavirus RNA replication". J Virol 73 (10): 8349–8355. PMC 112852. PMID 10482585.