CopA-like RNA
| CopA-like RNA | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of CopA | |
| Identifiers | |
| Symbol | CopA |
| Rfam | RF00042 |
| Other data | |
| RNA type | Gene; antisense |
| Domain(s) | Bacteria |
| SO | 0000644 |
CopA-like RNA is a family of non-coding RNAs found on the R1 plasmid.
In several groups of bacterial plasmids, antisense RNAs regulate copy number through inhibition of replication initiator protein synthesis. These RNAs are characterised by a long hairpin structure interrupted by several unpaired nucleotides or bulged loops. In plasmid R1, the inhibitory complex between the antisense RNA (CopA) and its target mRNA (CopT) is characterised by a four-way junction structure and a side-by-side helical alignment.[1][2][3]
References
- ↑ Nordgren, S; Slagter-Jager JG; Wagner GH (2001). "Real time kinetic studies of the interaction between folded antisense and target RNAs using surface plasmon resonance". J Mol Biol 310 (5): 1125–1134. doi:10.1006/jmbi.2001.4802. PMID 11502000.
- ↑ Gerhart E, Wagner H, Nordström K (1986). "Structural analysis of an RNA molecule involved in replication control of plasmid R1.". Nucleic Acids Res 14 (6): 2523–38. doi:10.1093/nar/14.6.2523. PMC 339680. PMID 2421250.
- ↑ Jelloul N, Bouzouita H, Belkahia A (1979). "[Significance of impedance tests in childhood deafness].". Tunis Med 57 (4-5): 236–40. PMID 555093.