Complement component 1s
Complement component 1S (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r ) is a protein involved in the complement system.[1][2][3][4]
C1s cleaves C4, which eventually leads to the production of the C4b-C2a form of C3-convertase.
Classical pathway. (Some labels are in Polish.)
References
- ↑ Sim, R.B. (1981). "T'he human complement system serine proteases C1r and C1s and their proenzymes". Methods Enzymol. 80: 26–42. PMID 6281620.
- ↑ MacKinnon, C.M., Carter, P.E., Smyth, S.J., Dunbar, B. and Fothergill, J.E. (1987). "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence". Eur. J. Biochem. 169: 547–553. doi:10.1111/j.1432-1033.1987.tb13644.x. PMID 3500856.
- ↑ Müller-Eberhard, H.J. (1988). "Molecular organization and function of the complement system". Annu. Rev. Biochem. 57: 321–347. doi:10.1146/annurev.bi.57.070188.001541. PMID 3052276.
- ↑ Skoog, M.T., Mehdi, S., Wiseman, J.S. and Bey, P. The specificity of two proteinases that cleave adjacent to arginine, C (1989). "1 esterase and acrosin, for peptide p-nitroanilide substrates". Biochim. Biophys. Acta 996 (1-2): 89–94. doi:10.1016/0167-4838(89)90099-x. PMID 2500154.
External links
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| Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
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| Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
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| Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
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