Combretastatin A-4 phosphate

Combretastatin A-4 phosphate

Systematic (IUPAC) name
Phosphoric acid mono-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenyl} ester
Clinical data
Identifiers
CAS Registry Number	Y
PubChem	CID 5351387
ChemSpider	4508406
Synonyms	CA4P; CA4PD; fosbretabulin; fosbretabulin disodium
Chemical data
Formula	C18H21O8P
Molecular mass	396.32 g/mol (exact mass : 396.097404)
SMILES O=P(O)(O)Oc1c(OC)ccc(c1)\C=C/c2cc(OC)c(OC)c(OC)c2
InChI InChI=1S/C18H21O8P/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3/h5-11H,1-4H3,(H2,19,20,21)/b6-5- Key:WDOGQTQEKVLZIJ-WAYWQWQTSA-N
Y (what is this?)  (verify)

For more information about this drug and its actions, see combretastatin.

Combretastatin A-4 phosphate (fosbretabulin, and its salt fosbretabulin disodium) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. It is a derivative of combretastatin.

Combretastatin A-4 phosphate is a prodrug. In vivo, it is dephosphorylated to its active metabolite, combretastatin A-4.^[1]

References