Climbazole

Climbazole

Systematic (IUPAC) name
(RS)-1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one[1]
Clinical data
Routes of administration	topical
Identifiers
CAS Registry Number	38083-17-9 Y
ATC code	None
PubChem	CID 37907
ChemSpider	34752
UNII	9N42CW7I54 Y
ChEBI	CHEBI:83499 N
ChEMBL	CHEMBL1437764 N
Chemical data
Formula	C15H17ClN2O2
Molecular mass	292.76
SMILES CC(C)(C)C(=O)C(n1ccnc1)Oc2ccc(cc2)Cl
InChI InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3 Key:OWEGWHBOCFMBLP-UHFFFAOYSA-N
N (what is this?)  (verify)

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff^[2] and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff.^[2] Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.

Indications and formulations

It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.

Side effects

May cause localized irritation of the skin with symptoms including redness, rashes and itching.

References