Clidinium bromide
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Systematic (IUPAC) name | |
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3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide | |
Clinical data | |
AHFS/Drugs.com | monograph |
MedlinePlus | a601036 |
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Oral | |
Pharmacokinetic data | |
Bioavailability | Low |
Excretion | Renal and biliary |
Identifiers | |
7020-55-5 ![]() | |
A03CA02 (combination with psycholeptics) | |
PubChem | CID 2784 |
IUPHAR ligand | 351 |
DrugBank |
DB00771 ![]() |
ChemSpider |
2682 ![]() |
UNII |
BO76JF850N ![]() |
ChEMBL |
CHEMBL1200950 ![]() |
Chemical data | |
Formula | C22H26NO3+ |
352.447 g/mol | |
SMILES
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Clidinium bromide (INN) is an anticholinergic (specifically a muscarinic antagonist) drug.[1] It may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines. It is commonly prescribed in combination with chlordiazepoxide (a benzodiazepine derivative) using the brand name Librax.
Uses
Peptic ulcer disease
Used in fixed combination with chlordiazepoxide as adjunctive therapy in the treatment of peptic ulcer disease; however, no conclusive data that antimuscarinics aid in the healing, decrease the rate of recurrence, or prevent complications of peptic ulcers.[2]
With the advent of more effective therapies for the treatment of peptic ulcer disease, antimuscarinics have only limited usefulness in this condition.
GI motility disturbances
Used in fixed combination with chlordiazepoxide in the treatment of functional GI motility disturbances (e.g., irritable bowel syndrome).
Has limited efficacy in treatment of GI motility disturbance and should only be used if other measures (e.g., diet, sedation, counseling, amelioration of environmental factors) have been of little or no benefit.
Acute enterocolitis
Used in fixed combination with chlordiazepoxide in the treatment of acute enterocolitis. However, antimuscarinics should be used with extreme caution in patients with diarrhea or ulcerative colitis.
Mechanism of action
Clidinium inhibits muscarinic acetylcholine receptors on smooth muscles, secretory glands, and in the central nervous system to relax smooth muscle and decrease biliary tract secretions.[3]
Preclinical studies
Clidinium is an effective anticholinergic agent with activity approximating that of atropine sulfate against spasms induced by acetylcholine in isolated intestinal strips. On oral administration in mice it proved an effective antisialagogue in preventing salivation induced by pilocarpine. Spontaneous intestinal motility in both rats and dogs is reduced following oral dosing with 0.1 to 0.25 mg/kg. Potent cholinergic ganglionic blocking effects (vagal) are produced with intravenous usage in anesthetized dogs.
Oral doses of 23 mg/kg administered to dogs produced nasal dryness and slight pupillary dilation. In two other species, monkeys and rabbits, doses of 5 mg/kg by mouth, three times a day, for 5 days produced no apparent changes.
References
- ↑ "Clidinium bromide". Drugs.com. Retrieved August 24, 2013.
- ↑ "Clidinium Bromide Monograph". Drugs.com. Retrieved August 24, 2013.
- ↑ 2014 Nurses Drug Handbook (13th ed.). Burlington, MA: Jones & Bartlett Learning. 2014. pp. 245–6. ISBN 978-1-284-03115-7.