Cilastatin
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Systematic (IUPAC) name | |
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(Z)-7-[(2R)-2-Amino-3-hydroxy-3-oxopropyl]sulfanyl-2-{[(1S)-2,2-dimethylcyclopropanecarbonyl]amino}hept-2-enoic acid | |
Clinical data | |
AHFS/Drugs.com | International Drug Names |
MedlinePlus | a686013 |
IV | |
Identifiers | |
82009-34-5 ![]() | |
J01DH51 (combination with imipenem) | |
PubChem | CID 5280454 |
DrugBank |
DB01597 ![]() |
ChemSpider |
4940183 ![]() |
UNII |
141A6AMN38 ![]() |
KEGG |
D07698 ![]() |
ChEBI |
CHEBI:3697 ![]() |
ChEMBL |
CHEMBL766 ![]() |
Chemical data | |
Formula | C16H26N2O5S |
358.454 g/mol | |
SMILES
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Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase.[1]
Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic activity.
Another carbapenem, meropenem is resistant to dehydropeptidase; therefore, it can be given without cilastatin.
See also
References
- ↑ Keynan S, Hooper NM, Felici A, Amicosante G, Turner AJ (1995). "The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA". Antimicrob. Agents Chemother. 39 (7): 1629–31. doi:10.1128/aac.39.7.1629. PMC 162797. PMID 7492120.