Chlornaphazine
![]() | |
Names | |
---|---|
IUPAC name
N,N-Bis(2-chloroethyl)naphthalen-2-amine | |
Other names
Chlornapazine; 2-Naphthylbis(chloroethyl)amine | |
Identifiers | |
494-03-1 | |
ChEMBL | ChEMBL2107519 |
ChemSpider | 9885 |
| |
Jmol-3D images | Image |
KEGG | C16446 ![]() |
PubChem | 10307 |
| |
Properties | |
Molecular formula |
C14H15Cl2N |
Molar mass | 268.18 g·mol−1 |
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
Infobox references | |
Chlornaphazine, a derivative of 2-naphthylamine, is a nitrogen mustard that was developed in the 1950s for the treatment of polycythemia and Hodgkin's disease.[1] However, a high incidence of bladder cancers in patients receiving treatment with chlornaphthazine led to use of the drug being discontinued.[2]
The International Agency for Research on Cancer has listed chlornaphazine as a human carcinogen.[3]
References
- ↑ Videbaek, A.; Kaae, S. (1954). "2-Naphthylbis(chloroethyl)amine in the treatment of malignant diseases, particularly Hodgkin's disease". Acta Medica Scandinavica 149 (5): 361–368. doi:10.1111/j.0954-6820.1954.tb11446.x. PMID 13180246.
- ↑ Benedicte Laursen (1970). "Cancer of the Bladder in Patients Treated with Chlornaphazine". Br Med J. 3 (5724): 684–685. doi:10.1136/bmj.3.5724.684. PMC 1701774. PMID 5470116.
- ↑ N,N-Bis(2-Chloroethyl)-2-Naphthylamine (Chlornaphazine), International Agency for Research on Cancer