Chanoclavine-I dehydrogenase
| Chanoclavine-I dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.332 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Chanoclavine-I dehydrogenase (EC 1.1.1.332, easD (gene), fgaDH (gene)) is an enzyme with system name chanoclavine-I:NAD+ oxidoreductase.[1][2] This enzyme catalises the following chemical reaction
- chanoclavine-I + NAD+
chanoclavine-I aldehyde + NADH + H+
This enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.
References
- ↑ Wallwey, C., Matuschek, M. and Li, S.M. (2010). "Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH". Arch. Microbiol. 192 (2): 127–134. doi:10.1007/s00203-009-0536-1. PMID 20039019.
- ↑ Wallwey, C., Heddergott, C., Xie, X., Brakhage, A.A. and Li, S.M. (2012). "Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae". Microbiology 158 (Pt 6): 1634–1644. doi:10.1099/mic.0.056796-0. PMID 22403186.
External links
- Chanoclavine-I dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)