Cerebral hemorrhage

Cerebral hemorrhage
CT scan of a spontaneous intracranial hemorrhage
Classification and external resources
ICD-10	I61, P10.1
ICD-9	431
DiseasesDB	mama.htm Yo mama
MeSH	D002543

A cerebral hemorrhage (also spelled haemorrhage; also known as a cerebral hematoma) is a type of intracranial hemorrhage (intracranial hematoma) that occurs within the brain tissue. It is alternatively called intracerebral hemorrhage. It can be caused by brain trauma, or it can occur spontaneously in hemorrhagic stroke. Non-traumatic intracerebral hemorrhage is a spontaneous bleeding into the brain tissue. Non-traumatic can refer to increased excertion, tension or stress.^[1]

A cerebral hemorrhage is an intra-axial hemorrhage; that is, it occurs within the brain tissue rather than outside of it. The other category of intracranial hemorrhage is extra-axial hemorrhage, such as epidural, subdural, and subarachnoid hematomas, which all occur within the skull but outside of the brain tissue. There are two main kinds of intra-axial hemorrhages: intraparenchymal hemorrhage and intraventricular hemorrhages. As with other types of hemorrhages within the skull, intraparenchymal bleeds are a serious medical emergency because they can increase intracranial pressure, which if left untreated can lead to coma and death. The mortality rate for intraparenchymal bleeds is over 40%.^[2]

The abbreviation ICH, somewhat ambiguous, has been used for any combination of intracranial/intracerebral + hemorrhage/hematoma/hypertension.

Signs and symptoms

Patients with intraparenchymal bleeds have symptoms that correspond to the functions controlled by the area of the brain that is damaged by the bleed.^[3] Other symptoms include those that indicate a rise in intracranial pressure caused by a large mass putting pressure on the brain.^[3] Intracerebral hemorrhages are often misdiagnosed as subarachnoid hemorrhages due to the similarity in symptoms and signs. A severe headache followed by vomiting is one of the more common symptoms of intracerebral hemorrhage. Some patients may also go into a coma before the bleed is noticed.

Causes

Splenial Infarct / Boomerang Sign, Sturge Weber Syndrome / Vein of Galen Malformation

Axial CT scan showing hemorrhage in the posterior fossa^[1]

Intracerebral bleeds are the second most common cause of stroke, accounting for 10% of hospital admissions for stroke.^[4] High blood pressure raises the risks of spontaneous intracerebral hemorrhage by two to six times.^[1] More common in adults than in children, intraparenchymal bleeds are usually due to penetrating head trauma, but can also be due to depressed skull fractures. Acceleration-deceleration trauma,^[5][6][7] rupture of an aneurysm or arteriovenous malformation (AVM), and bleeding within a tumor are additional causes. Amyloid angiopathy is a not uncommon cause of intracerebral hemorrhage in patients over the age of 55. A very small proportion is due to cerebral venous sinus thrombosis. Infection with the k serotype of Streptococcus mutans may also be a risk factor, because of its prevalence in stroke patients and production of collagen-binding protein.^[8]

Risk factors for ICH include:^[9]

• Hypertension (high blood pressure)
• Diabetes mellitus
• Menopause
• Cigarette smoking
• Excessive alcohol consumption
• Severe migraine

Tramautic intracerebral hematomas are divided into acute and delayed. Acute intracerebral hematomas occur at the time of the injury while delayed intracerebral hematomas have been reported from as early as 6 hours post injury to as long as several weeks.

Diagnosis

Spontaneous ICH with hydrocephalus on CT scan^[1]

Both computed tomography angiography (CTA) and magnetic resonance angiography (MRA) have been proved to be effective in diagnosing intracranial vascular malformations after ICH.^[10] So frequently, a CT angiogram will be performed in order to exclude a secondary cause of hemorrhage^[11] or to detect a "spot sign".

Intraparenchymal hemorrhage can be recognized on CT scans because blood appears brighter than other tissue and is separated from the inner table of the skull by brain tissue. The tissue surrounding a bleed is often less dense than the rest of the brain because of edema, and therefore shows up darker on the CT scan.^[11]

Treatment

Treatment depends substantially of the type of ICH. Rapid CT scan and other diagnostic measures are used to determine proper treatment, which may include both medication and surgery.

Medication

• Antihypertensive therapy to bring down the blood pressure in acute phases appears to improve outcomes.^[12] The AHA/ASA and EUSI guidelines (American Heart Association/American Stroke Association guidelines, and the European Stroke Initiative guidelines) have recommended antihypertensive therapy to stabilize the mean arterial pressure at 110 mmHg.
• Giving Factor VIIa within 4 hours limits the bleeding and formation of a hematoma. However, it also increases the risk of thromboembolism.^[13] It thus overall does not result in better outcomes in those without hemophilia.^[14]
• Mannitol is effective in acutely reducing raised intracranial pressure.
• Acetaminophen may be needed to avoid hyperthermia, and to relieve headache.^[13]
• Frozen plasma, vitamin K, protamine, or platelet transfusions are given in case of a coagulopathy.^[13]
• Fosphenytoin or other anticonvulsant is given in case of seizures or lobar hemorrhage.^[13]
• H2 antagonists or proton pump inhibitors are commonly given for stress ulcer prophylaxis, a condition somehow linked with ICH.^[13]
• Corticosteroids, were thought to reduce swelling. However, in large controlled studies, corticosteroids haven been found to increase mortality rates and are no longer recommended.^[15][16]

Surgery

Surgery is required if the hematoma is greater than 3 cm (1 in), if there is a structural vascular lesion or lobar hemorrhage in a young patient.^[13]

• A catheter may be passed into the brain vasculature to close off or dilate blood vessels, avoiding invasive surgical procedures.^[17]
• Aspiration by stereotactic surgery or endoscopic drainage may be used in basal ganglia hemorrhages, although successful reports are limited.^[13]

Other treatment

• Tracheal intubation is indicated in patients with decreased level of consciousness or other risk of airway obstruction.^[13]
• IV fluids are given to maintain fluid balance, using isotonic rather than hypotonic fluids.^[13]

Prognosis

The risk of death from an intraparenchymal bleed in traumatic brain injury is especially high when the injury occurs in the brain stem.^[2] Intraparenchymal bleeds within the medulla oblongata are almost always fatal, because they cause damage to cranial nerve X, the vagus nerve, which plays an important role in blood circulation and breathing.^[5] This kind of hemorrhage can also occur in the cortex or subcortical areas, usually in the frontal or temporal lobes when due to head injury, and sometimes in the cerebellum.^[5][18]

For spontaneous ICH seen on CT scan, the death rate (mortality) is 34–50% by 30 days after the insult,^[1] and half of the deaths occur in the first 2 days.^[19] Even though the majority of deaths occurs in the first days after ICH, survivors have a long term excess mortality of 27% compared to the general population.^[20]

The inflammatory response triggered by stroke has been viewed as harmful in the early stage, focusing on blood-borne leukocytes, neutrophils and macrophages, and resident microglia and astrocytes.^[21] A human postmortem study shows that inflammation occurs early and persists for several days after ICH.^[22] New area of interest are the Mast Cells.^[23]

Epidemiology

It accounts for 20% of all cases of cerebrovascular disease in the US, behind cerebral thrombosis (40%) and cerebral embolism (30%).^[24]

It is two or more times more prevalent in black patients than it is in white patients.^[25]

Notable people who died from ICH

In 1945, U.S President Franklin D. Roosevelt died from a cerebral hemorrhage.

In 1951 Russian-born American pianist Simon Barere collapsed and later died from cerebral hemorrhage. ^[26]

In 1985, television game show announcer Johnny Olson died from a cerebral hemorrhage.

In 1953, Joseph Stalin died from a cerebral hemorrhage.

In 1962, Stuart Sutcliffe, the original bassist for the Beatles died from a cerebral hemorrhage.

In 1967 Nelson Eddy died from a cerebral hemorrhage.

In 1978, the singer Sandy Denny died as a result of a traumatic mid-brain hemorrhage and blunt force trauma to her head.

In 1994 Michael O'Donoghue, Saturday Night Live writer/featured player, died from a cerebral hemorrhage after a long history of what were thought to be chronic migraine headaches.

In 2015, the actor Jonathan Crombie of Anne of Green Gables, died from a cerebral hemorrhage at the age of 48.

References

External links

Wikimedia Commons has media related to Cerebral hemorrhage.

• Parent friendly information on IVH in premature babies from The Hospital for Sick Children
• LPCH on Intraventricular
• Information on brain haemorrhage from Headway - the brain injury association, a UK-based charity providing information and support