Central Institute for Experimental Animals
Coordinates: 35°32′19.84″N 139°45′40.93″E / 35.5388444°N 139.7613694°E
| Formation | 1952 |
|---|---|
| Headquarters | Kawasaki, Kanagawa, Japan |
Director | Tatsuji Nomura |
| Website | http://www.ciea.or.jp/en/index.html |
Central Institute for Experimental Animals (CIEA) (実験動物中央研究所) is a research center for experimental animals in Japan. It was founded by Tatsuji Nomura in 1952 with the mission of improving the level of biomedical research.
Main achievements and ongoing projects
- Establishment of the world first and only monitoring center for experimental animals in 1970. Appointed as an International Council for Laboratory Animal Science (ICLAS) Monitoring Center in 1979.
- Development and establishment of Tg-PVR mouse, in which a human poliovirus receptor gene is introduced, used as a safety testing for oral polio vaccine.
- Establishment of Tg-rasH2 mouse, in which a human prototype c-Ha-ras oncogene is introduced, and evaluation of their practical usefulness. Achieved a high level of accuracy in carcinogenicity testing for drugs and reduced the testing period to six months from the conventional two years' system.[1]
- Developing spinal cord injury model and Parkinson's disease model using the common marmoset (New World monkey).
- Establishment of a severe immunodeficient mouse, NOD/Shi-scid, IL-2Rγnull mouse (NOD/SCID/IL-2Rγnull mouse, NOG mouse) and development of its applications to various animal experiments and testing systems.
History
- 1952 Founded in Nishitama District, Tokyo, Japan
- 1957 Authorized as a non-profit research organization under Ministry of Education, Japan
- 1962 Specific Pathogen Free (SPF) animal production facility was established in Nogawa, Kawasaki, Japan
- 1965 Animal production and supply department was spun off as CLEA Japan, Inc.
- 1966 Preclinical Research Laboratory was established
- 1969 Germ-free animal facility was established
- 1973 Bioscience Research Department was established
- 1976 Organized "The 2nd International Workshop on Nude Mice", Tokyo, Chairman T. Nomura
- 1979 Appointed as ICLAS Monitoring Center
- 1982 Embryological Engineering Laboratory was established
- 1985 Laboratory animal monitoring facilities completed
- 1987 Developmental Engineering Experiment Manual published
- 1988 High priority "Laboratory animal monitoring project" started
- 1991 From Six Mice: History of Central Institute for Experimental Animals published
- 1992 Laboratory Animal Cryopreservation Facilities completed
- 2001 Center for the Advancement of Health and Biosciences (CAHB) established as a nonprofit organization in the United States
- 2002 Global business development was initiated
- 2005 NOG mouse patent granted
- 2006 Tatsuji Nomura becomes Chairman of the Board of Directors of CIEA
- 2006 Organized "The 1st International Workshop on Humanized Mice", Tokyo, Chairman T. Nomura
External links
- CIEA website
- Monitoring Center (Japanese)
- Tg-rasH2 mice
- NOG mice
References
- ↑ James MacDonald and et al. (2004). "The Utility of Genetically Modified Mouse Assays for Identifying Human Carcinogens: A Basic Understanding and Path Forward". Toxicological Sciences 77 (2): 188–194. doi:10.1093/toxsci/kfh037. PMID 14657512.