Center for Pharmaceutical Research and Innovation

The Center for Pharmaceutical Research and Innovation (CPRI) is a University of Kentucky-based research center established by the University of Kentucky College of Pharmacy in 2011 to facilitate academic translational research and drug discovery/drug development. The UK CPRI specializes in natural product-based drug discovery from microbes found within unique environments including underground and surface coal mines, acid mine drainage and mine reclamation sites, thermal vents associated with underground coal mine fires (see coal seam fire)[1][2][3] and deep-well drilling for carbon sequestration.

References

  1. ↑ Ohlson, K. "Earth On Fire." Discover Magazine 2010, July–August Special Issue.
  2. ↑ Wang, X; Elshahawi, SI; Shaaban, KA; Fang, L; Ponomareva, LV; Zhang, Y; Copley, GC; Hower, JC; Zhan, CG; Kharel, MK; Thorson, JS (Jan 17, 2014). "Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15". Organic Letters 16 (2): 456–9. doi:10.1021/ol4033418. PMID 24341358.
  3. ↑ Wang, X; Shaaban, KA; Elshahawi, SI; Ponomareva, LV; Sunkara, M; Copley, GC; Hower, JC; Morris, AJ; Kharel, MK; Thorson, JS (Aug 2014). "Mullinamides A and B, new cyclopeptides produced by the Ruth Mullins coal mine fire isolate Streptomyces sp. RM-27-46.". The Journal of Antibiotics 67 (8): 571–5. doi:10.1038/ja.2014.37. PMID 24713874.

External links