Caveolin 1

Caveolin 1, caveolae protein, 22kDa
Identifiers
Symbols	CAV1 ; BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21
External IDs	OMIM: 601047 MGI: 102709 HomoloGene: 1330 GeneCards: CAV1 Gene
Gene ontology Molecular function • receptor binding • patched binding • structural molecule activity • protein binding • cholesterol binding • peptidase activator activity • enzyme binding • protein complex scaffold • nitric-oxide synthase binding Cellular component • Golgi membrane • acrosomal membrane • intracellular • endosome • endoplasmic reticulum • lipid particle • plasma membrane • integral component of plasma membrane • caveola • cilium • cell cortex • basolateral plasma membrane • apical plasma membrane • endocytic vesicle membrane • cytoplasmic vesicle • protein complex • membrane raft • perinuclear region of cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • MAPK cascade • inactivation of MAPK activity • angiogenesis • vasculogenesis • response to hypoxia • negative regulation of endothelial cell proliferation • negative regulation of cytokine-mediated signaling pathway • response to ischemia • regulation of the force of heart contraction by chemical signal • triglyceride metabolic process • calcium ion transport • cellular calcium ion homeostasis • regulation of smooth muscle contraction • skeletal muscle tissue development • lactation • blood coagulation • protein localization • cellular response to starvation • positive regulation of calcium ion transport into cytosol • positive regulation of peptidase activity • viral process • vesicle organization • regulation of fatty acid metabolic process • lipid storage • regulation of blood coagulation • cholesterol transport • negative regulation of BMP signaling pathway • negative regulation of epithelial cell differentiation • mammary gland development • T cell costimulation • negative regulation of protein ubiquitination • negative regulation of protein binding • maintenance of protein location in cell • response to progesterone • negative regulation of peptidyl-serine phosphorylation • positive regulation of peptidyl-serine phosphorylation • nitric oxide homeostasis • vasoconstriction • negative regulation of tyrosine phosphorylation of Stat5 protein • cholesterol homeostasis • negative regulation of MAPK cascade • response to estrogen • small molecule metabolic process • negative regulation of nitric oxide biosynthetic process • positive regulation of vasoconstriction • nitric oxide metabolic process • negative regulation of JAK-STAT cascade • negative regulation of pinocytosis • positive regulation of metalloenzyme activity • leukocyte migration • regulation of nitric-oxide synthase activity • negative regulation of nitric-oxide synthase activity • protein homooligomerization • cytosolic calcium ion homeostasis • response to calcium ion • membrane depolarization • regulation of peptidase activity • calcium ion homeostasis • mammary gland involution • caveola assembly • cellular response to hyperoxia • caveolin-mediated endocytosis • negative regulation of canonical Wnt signaling pathway • positive regulation of canonical Wnt signaling pathway • apoptotic signaling pathway • receptor internalization involved in canonical Wnt signaling pathway • negative regulation of anoikis • positive regulation of extrinsic apoptotic signaling pathway • positive regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	857	12389
Ensembl	ENSG00000105974	ENSMUSG00000007655
UniProt	Q03135	P49817
RefSeq (mRNA)	NM_001172895	NM_001243064
RefSeq (protein)	NP_001166366	NP_001229993
Location (UCSC)	Chr 7: 116.16 – 116.2 Mb	Chr 6: 17.31 – 17.34 Mb
PubMed search

Caveolin-1 is a protein that in humans is encoded by the CAV1 gene.^[1]

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.^[2]

Interactions

Caveolin 1 has been shown to interact with heterotrimeric G proteins,^[3] Src tyrosine kinases (Src, Lyn) and H-Ras,^[4] cholesterol,^[5] TGF beta receptor 1,^[6] Endothelial NOS,^[7] Androgen receptor,^[8] Amyloid precursor protein,^[9] Gap junction protein, alpha 1,^[10] Nitric oxide synthase 2A,^[11] Epidermal growth factor receptor,^[12] Endothelin receptor type B,^[13] PDGFRB,^[14] PDGFRA,^[14] PTGS2,^[15] TRAF2,^[16][17] Estrogen receptor alpha,^[18] Caveolin 2,^[19][20] PLD2,^[21][22] Bruton's tyrosine kinase^[23] and SCP2.^[24] All these interactions are through a caveolin-scaffolding domain (CSD) within caveolin-1 molecule.^[4] Molecules that interact with caveolin-1 contain caveolin-binding motifs (CBM).^[25]

See also

• Caveolin

References

Further reading