Caroverine

Caroverine
Systematic (IUPAC) name
1-[2-(diethylamino)ethyl]- 3-(4-methoxybenzyl)quinoxalin- 2(1H)-one
Clinical data
  • ℞ (Prescription only)
Oral
Identifiers
23465-76-1 Yes
A03AX11
PubChem CID 65709
ChemSpider 59135 Yes
UNII XJ73B0K6KB Yes
ChEMBL CHEMBL1729803 
Chemical data
Formula C22H27N3O2
365.47 g/mol
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Caroverine (Spasmium, Spadon, Tinnex) is a drug used as a spasmolytic and otoneuroprotective (inner ear protective) agent in some countries.[1] It acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist.[1] It also has potent antioxidant effects.[1][2]

Applications

Caroverine has been demonstrated to have a high rate of efficacy in the treatment of cochlear-synaptic tinnitus.[3]

See also

References

  1. ↑ 1.0 1.1 1.2 Udilova N, Kozlov AV, Bieberschulte W, Frei K, Ehrenberger K, Nohl H (2003). "The Antioxidant Activity of Caroverine". Biochemical Pharmacology 65 (1): 59–65. doi:10.1016/S0006-2952(02)01452-1. PMID 12473379.
  2. ↑ Nohl H, Bieberschulte W, Dietrich B, Udilova N, Kozlov AV (2003). "Caroverine, a Multifunctional Drug with Antioxidant Functions". BioFactors 19 (1–2): 79–85. doi:10.1002/biof.5520190110. PMID 14757980.
  3. ↑ Denk DM, Heinzl H, Franz P, Ehrenberger K. (Nov 1997). "Caroverine in tinnitus treatment. A placebo-controlled blind study.". Acta Oto-Laryngologica 117: 825–30. doi:10.3109/00016489709114208. PMID 9442821.