Carbonic anhydrase II

"CA II" redirects here. For the spectral features of calcium, see Calcium § H_and_K_lines.
Carbonic anhydrase II

PDB rendering based on 12ca[1].
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCA2 ; CA-II; CAC; CAII; Car2; HEL-76
External IDsOMIM: 611492 MGI: 88269 HomoloGene: 37256 ChEMBL: 205 GeneCards: CA2 Gene
EC number4.2.1.1
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez76012349
EnsemblENSG00000104267ENSMUSG00000027562
UniProtP00918P00920
RefSeq (mRNA)NM_000067NM_009801
RefSeq (protein)NP_000058NP_033931
Location (UCSC)Chr 8:
86.38 – 86.39 Mb
Chr 3:
14.89 – 14.9 Mb
PubMed search

Carbonic anhydrase II (gene name CA2), is one of fourteen forms of human α carbonic anhydrases. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of sodium ions in the proximal tubule. [2]

Interactions

Carbonic anhydrase II has been shown to interact with Band 3[3][4][5][6] and Sodium-hydrogen antiporter 1.[7]

References

  1. Nair, S. K.; Calderone, T. L.; Christianson, D. W.; Fierke, C. A. (1991). "Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121". The Journal of biological chemistry 266 (26): 17320–17325. PMID 1910042.
  2. "Entrez Gene: CA2 carbonic anhydrase II".
  3. Sterling, D; Reithmeier R A; Casey J R (December 2001). "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers". J. Biol. Chem. (United States) 276 (51): 47886–94. doi:10.1074/jbc.M105959200. ISSN 0021-9258. PMID 11606574.
  4. Vince, J W; Reithmeier R A (October 1998). "Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte C1-/HCO3- exchanger". J. Biol. Chem. (UNITED STATES) 273 (43): 28430–7. doi:10.1074/jbc.273.43.28430. ISSN 0021-9258. PMID 9774471.
  5. Vince, J W; Carlsson U; Reithmeier R A (November 2000). "Localization of the Cl-/HCO3- anion exchanger binding site to the amino-terminal region of carbonic anhydrase II". Biochemistry (UNITED STATES) 39 (44): 13344–9. doi:10.1021/bi0015111. ISSN 0006-2960. PMID 11063570.
  6. Vince, J W; Reithmeier R A (May 2000). "Identification of the carbonic anhydrase II binding site in the Cl(-)/HCO(3)(-) anion exchanger AE1". Biochemistry (UNITED STATES) 39 (18): 5527–33. doi:10.1021/bi992564p. ISSN 0006-2960. PMID 10820026.
  7. Li, Xiuju; Alvarez Bernardo; Casey Joseph R; Reithmeier Reinhart A F; Fliegel Larry (September 2002). "Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger". J. Biol. Chem. (United States) 277 (39): 36085–91. doi:10.1074/jbc.M111952200. ISSN 0021-9258. PMID 12138085.

Further reading