Calicivirin

Calicivirin
Identifiers
EC number 3.4.22.66
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Calicivirin (EC 3.4.22.66, Camberwell virus processing peptidase, Chiba virus processing peptidase, Norwalk virus processing peptidase, Southampton virus processing peptidase, norovirus virus processing peptidase, calicivirus trypsin-like cysteine protease, calicivirus TCP, calicivirus 3C-like protease, calicivirus endopeptidase, rabbit hemorrhagic disease virus 3C endopeptidase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu- and the P1- position is occupied by Gly-

Viruses that are members of the Norovirus genus (Caliciviridae family) are a major cause of epidemic acute viral gastroenteritis.

References

  1. ↑ Meyers, G., Rossi, C. and Thiel, H.J. (2004). "Calicivirus endopeptidases". In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. pp. 1380–1382.
  2. ↑ Wirblich, C., Sibilia, M., Boniotti, M.B., Rossi, C., Thiel, H.J. and Meyers, G. (1995). "3C-like protease of rabbit hemorrhagic disease virus: identification of cleavage sites in the ORF1 polyprotein and analysis of cleavage specificity". J. Virol. 69: 7159–7168. PMID 7474137.
  3. ↑ Martín Alonso, J.M., Casais, R., Boga, J.A. and Parra, F. (1996). "Processing of rabbit hemorrhagic disease virus polyprotein". J. Virol. 70: 1261–1265. PMID 8551592.
  4. ↑ Liu, B., Clarke, I.N. and Lambden, P.R. (1996). "Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis". J. Virol. 70: 2605–2610. PMID 8642693.
  5. ↑ Liu, B.L., Viljoen, G.J., Clarke, I.N. and Lambden, P.R. (1999). "Identification of further proteolytic cleavage sites in the Southampton calicivirus polyprotein by expression of the viral protease in E. coli". J. Gen. Virol. 80: 291–296. PMID 10073687.

External links