CYP4F11
| Cytochrome P450, family 4, subfamily F, polypeptide 11 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CYP4F11 ; CYPIVF11 | ||||||||||||
| External IDs | OMIM: 611517 MGI: 3645508 HomoloGene: 117991 IUPHAR: 1347 GeneCards: CYP4F11 Gene | ||||||||||||
| EC number | 1.14.14.1 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 57834 | 631304 | |||||||||||
| Ensembl | ENSG00000171903 | ENSMUSG00000090700 | |||||||||||
| UniProt | Q9HBI6 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001128932 | NM_001101588 | |||||||||||
| RefSeq (protein) | NP_001122404 | NP_001095058 | |||||||||||
| Location (UCSC) | Chr 19: 16.02 – 16.05 Mb | Chr 17: 32.66 – 32.68 Mb | |||||||||||
| PubMed search | |||||||||||||
CYP4F11 (cytochrome P450, family 4, subfamily F, polypeptide 11) is a protein that in humans is encoded by the CYP4F11 gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[2]
References
- ↑ Cui X, Nelson DR, Strobel HW (September 2000). "A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization". Genomics 68 (2): 161–6. doi:10.1006/geno.2000.6276. PMID 10964514.
- ↑ "Entrez Gene: CYP4F11".
Further reading
- Dhar M, Sepkovic DW, Hirani V et al. (2008). "Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.". J. Lipid Res. 49 (3): 612–24. doi:10.1194/jlr.M700450-JLR200. PMID 18065749.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Grimwood J, Gordon LA, Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Nelson DR, Zeldin DC, Hoffman SM et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
- Simpson AE (1997). "The cytochrome P450 4 (CYP4) family". Gen. Pharmacol. 28 (3): 351–9. doi:10.1016/S0306-3623(96)00246-7. PMID 9068972.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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