CYP4A22
| Cytochrome P450, family 4, subfamily A, polypeptide 22 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbol | CYP4A22 | ||||||||||||
| External IDs | OMIM: 615341 MGI: 88612 HomoloGene: 134044 IUPHAR: 1342 GeneCards: CYP4A22 Gene | ||||||||||||
| EC number | 1.14.15.3 | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 284541 | 13118 | |||||||||||
| Ensembl | ENSG00000162365 | ENSMUSG00000078597 | |||||||||||
| UniProt | Q5TCH4 | B0G0Y2 | |||||||||||
| RefSeq (mRNA) | NM_001010969 | NM_172306 | |||||||||||
| RefSeq (protein) | NP_001010969 | NP_758510 | |||||||||||
| Location (UCSC) | Chr 1: 47.39 – 47.41 Mb | Chr 4: 115.41 – 115.44 Mb | |||||||||||
| PubMed search | |||||||||||||
CYP4A22 (cytochrome P450, family 4, subfamily A, polypeptide 22) also known as fatty acid omega-hydroxylase is a protein which in humans is encoded by the CYP4A22 gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.[2]
References
- ↑ Hiratsuka M, Nozawa H, Katsumoto Y, Moteki T, Sasaki T, Konno Y, Mizugaki M (July 2006). "Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population". Mutat. Res. 599 (1–2): 98–104. doi:10.1016/j.mrfmmm.2006.02.008. PMID 16806293.
- ↑ "Entrez Gene: CYP4A22".
Further reading
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bellamine A, Wang Y, Waterman MR et al. (2003). "Characterization of the CYP4A11 gene, a second CYP4A gene in humans". Arch. Biochem. Biophys. 409 (1): 221–7. doi:10.1016/S0003-9861(02)00545-3. PMID 12464262.
- Gainer JV, Bellamine A, Dawson EP et al. (2005). "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation 111 (1): 63–9. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369.
- Nelson DR, Zeldin DC, Hoffman SM et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| ||||||||||||||||||||||||||