CYP4A11

Cytochrome P450, family 4, subfamily A, polypeptide 11
Identifiers
SymbolsCYP4A11 ; CP4Y; CYP4A2; CYP4AII
External IDsOMIM: 601310 MGI: 88611 HomoloGene: 128044 IUPHAR: 1341 ChEMBL: 3978 GeneCards: CYP4A11 Gene
EC number1.14.15.3
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez157913117
EnsemblENSG00000162365ENSMUSG00000066072
UniProtQ02928O88833
RefSeq (mRNA)NM_000778NM_010011
RefSeq (protein)NP_000769NP_034141
Location (UCSC)Chr 1:
47.39 – 47.41 Mb		Chr 4:
115.52 – 115.53 Mb
PubMed search

Cytochrome P450 4A11 is a protein that in humans is encoded by the CYP4A11 gene.[1][2]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.[2]

References

  1. ↑ Palmer CN, Richardson TH, Griffin KJ, Hsu MH, Muerhoff AS, Clark JE, Johnson EF (Mar 1993). "Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli". Biochim Biophys Acta 1172 (1–2): 161–6. doi:10.1016/0167-4781(93)90285-L. PMID 7679927.
  2. ↑ 2.0 2.1 "Entrez Gene: CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11".

Further reading

  • Kawashima H, Kusunose E, Kubota I et al. (1992). "Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases". Biochim. Biophys. Acta 1123 (2): 156–62. doi:10.1016/0005-2760(92)90106-6. PMID 1739747.
  • Kawashima H, Kusunose E, Kikuta Y et al. (1995). "Purification and cDNA cloning of human liver CYP4A fatty acid omega-hydroxylase". J. Biochem. 116 (1): 74–80. PMID 7798189.
  • Imaoka S, Ogawa H, Kimura S, Gonzalez FJ (1994). "Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney". DNA Cell Biol. 12 (10): 893–9. doi:10.1089/dna.1993.12.893. PMID 8274222.
  • Bell DR, Plant NJ, Rider CG et al. (1993). "Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs". Biochem. J. 294 (1): 173–80. PMC 1134581. PMID 8363569.
  • Powell PK, Wolf I, Lasker JM (1996). "Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes". Arch. Biochem. Biophys. 335 (1): 219–26. doi:10.1006/abbi.1996.0501. PMID 8914854.
  • Powell PK, Wolf I, Jin R, Lasker JM (1998). "Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11". J. Pharmacol. Exp. Ther. 285 (3): 1327–36. PMID 9618440.
  • Chang YT, Loew GH (1999). "Homology modeling and substrate binding study of human CYP4A11 enzyme". Proteins 34 (3): 403–15. doi:10.1002/(SICI)1097-0134(19990215)34:3<403::AID-PROT12>3.0.CO;2-D. PMID 10024026.
  • Lasker JM, Chen WB, Wolf I et al. (2000). "Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11". J. Biol. Chem. 275 (6): 4118–26. doi:10.1074/jbc.275.6.4118. PMID 10660572.
  • Kawashima H, Naganuma T, Kusunose E et al. (2000). "Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein". Arch. Biochem. Biophys. 378 (2): 333–9. doi:10.1006/abbi.2000.1831. PMID 10860550.
  • Hoch U, Ortiz De Montellano PR (2001). "Covalently linked heme in cytochrome p4504a fatty acid hydroxylases". J. Biol. Chem. 276 (14): 11339–46. doi:10.1074/jbc.M009969200. PMID 11139583.
  • Gonzalez MC, Marteau C, Franchi J, Migliore-Samour D (2001). "Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation". Br. J. Dermatol. 145 (5): 749–57. doi:10.1046/j.1365-2133.2001.04490.x. PMID 11736898.
  • LeBrun LA, Hoch U, Ortiz de Montellano PR (2002). "Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family". J. Biol. Chem. 277 (15): 12755–61. doi:10.1074/jbc.M112155200. PMID 11821421.
  • Savas U, Hsu MH, Johnson EF (2003). "Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone". Arch. Biochem. Biophys. 409 (1): 212–20. doi:10.1016/S0003-9861(02)00499-X. PMID 12464261.
  • Bellamine A, Wang Y, Waterman MR et al. (2003). "Characterization of the CYP4A11 gene, a second CYP4A gene in humans". Arch. Biochem. Biophys. 409 (1): 221–7. doi:10.1016/S0003-9861(02)00545-3. PMID 12464262.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jin P, Fu GK, Wilson AD et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.
  • Ramírez J, Innocenti F, Schuetz EG et al. (2005). "CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes". Drug Metab. Dispos. 32 (9): 930–6. PMID 15319333.
  • Gainer JV, Bellamine A, Dawson EP et al. (2005). "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation 111 (1): 63–9. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369.
  • Mayer B, Lieb W, Götz A et al. (2005). "Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy". Hypertension 46 (4): 766–71. doi:10.1161/01.HYP.0000182658.04299.15. PMID 16144986.