CYP3A7

Cytochrome P450, family 3, subfamily A, polypeptide 7
Identifiers
SymbolsCYP3A7 ; CP37; CYPIIIA7; P450-HFLA
External IDsOMIM: 605340 HomoloGene: 81129 IUPHAR: 1339 GeneCards: CYP3A7 Gene
EC number1.14.14.1
Orthologs
SpeciesHumanMouse
Entrez1551n/a
EnsemblENSG00000160870n/a
UniProtP24462n/a
RefSeq (mRNA)NM_000765n/a
RefSeq (protein)NP_000756n/a
Location (UCSC)Chr 7:
99.3 – 99.33 Mb		n/a
PubMed searchn/a

CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.[1] The gene location is 7q22.1.[2]

The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.[3]

References

  1. ↑ Komori M, Nishio K, Ohi H, Kitada M, Kamataki T (February 1989). "Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. PMID 2722762.
  2. ↑ "Cytochrome P450, Subfamily IIIA, Polypeptide 7". OMIM. Retrieved March 14, 2013.
  3. ↑ Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M (July 2000). "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans". Pharmacogenetics 10 (5): 415–24. doi:10.1097/00008571-200007000-00005. PMID 10898111.

External links