CYP3A43
| Cytochrome P450, family 3, subfamily A, polypeptide 43 | |||||||||||||
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| Symbols | CYP3A43 ; MGC119315; MGC119316 | ||||||||||||
| External IDs | OMIM: 606534 MGI: 1930638 HomoloGene: 136124 IUPHAR: 1340 ChEMBL: 5792 GeneCards: CYP3A43 Gene | ||||||||||||
| EC number | 1.14.14.1 | ||||||||||||
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| Species | Human | Mouse | |||||||||||
| Entrez | 64816 | 56388 | |||||||||||
| Ensembl | ENSG00000021461 | ENSMUSG00000029630 | |||||||||||
| UniProt | Q9HB55 | O09158 | |||||||||||
| RefSeq (mRNA) | NM_001278921 | NM_019792 | |||||||||||
| RefSeq (protein) | NP_001265850 | NP_062766 | |||||||||||
| Location (UCSC) | Chr 7: 99.83 – 99.87 Mb | Chr 5: 145.98 – 146.01 Mb | |||||||||||
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Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.[1][2][3]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.[3]
References
- ↑ Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG (Feb 2001). "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450". Mol Pharmacol 59 (2): 386–92. PMID 11160876.
- ↑ Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L (Mar 2001). "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene". Pharmacogenetics 11 (2): 111–21. doi:10.1097/00008571-200103000-00002. PMID 11266076.
- ↑ 3.0 3.1 "Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43".
Further reading
- Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.
- Finta C, Zaphiropoulos PG (2001). "The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons". Gene 260 (1–2): 13–23. doi:10.1016/S0378-1119(00)00470-4. PMID 11137287.
- Westlind A, Malmebo S, Johansson I et al. (2001). "Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43". Biochem. Biophys. Res. Commun. 281 (5): 1349–55. doi:10.1006/bbrc.2001.4505. PMID 11243885.
- Finta C, Zaphiropoulos PG (2002). "Intergenic mRNA molecules resulting from trans-splicing". J. Biol. Chem. 277 (8): 5882–90. doi:10.1074/jbc.M109175200. PMID 11726664.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Cauffiez C, Lo-Guidice JM, Chevalier D et al. (2004). "First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant". Hum. Mutat. 23 (1): 101. doi:10.1002/humu.9211. PMID 14695544.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
- Stone A, Ratnasinghe LD, Emerson GL et al. (2005). "CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians". Cancer Epidemiol. Biomarkers Prev. 14 (5): 1257–61. doi:10.1158/1055-9965.EPI-04-0534. PMID 15894682.
- Thompson EE, Kuttab-Boulos H, Yang L et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347. PMID 16314882.
- Shchepotina EG, Nikishina MV, Vavilin VA, Lyakhovich VV (2006). "Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia". Bull. Exp. Biol. Med. 140 (6): 726–8. doi:10.1007/s10517-006-0067-6. PMID 16848237.
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