CYP2W1
| Cytochrome P450, family 2, subfamily W, polypeptide 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CYP2W1 ; MGC34287 | ||||||||||||
| External IDs | MGI: 3616076 HomoloGene: 69239 IUPHAR: 1336 GeneCards: CYP2W1 Gene | ||||||||||||
| EC number | 1.14.14.- | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 54905 | 545817 | |||||||||||
| Ensembl | ENSG00000073067 | ENSMUSG00000029541 | |||||||||||
| UniProt | Q8TAV3 | E9Q816 | |||||||||||
| RefSeq (mRNA) | NM_017781 | NM_001160265 | |||||||||||
| RefSeq (protein) | NP_060251 | NP_001153737 | |||||||||||
| Location (UCSC) | Chr 7: 1.02 – 1.03 Mb | Chr 5: 139.35 – 139.36 Mb | |||||||||||
| PubMed search | |||||||||||||
CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.[2] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.
References
- ↑ Gerhard DS, Wagner L, Feingold EA et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- ↑ "Entrez Gene: CYP2W1".
Further reading
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hanzawa Y, Sasaki T, Mizugaki M et al. (2008). "Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population". Drug Metab. Dispos. 36 (2): 349–52. doi:10.1124/dmd.107.019141. PMID 17998294.
- Yoshioka H, Kasai N, Ikushiro S et al. (2006). "Enzymatic properties of human CYP2W1 expressed in Escherichia coli". Biochem. Biophys. Res. Commun. 345 (1): 169–74. doi:10.1016/j.bbrc.2006.04.080. PMID 16677611.
- Karlgren M, Gomez A, Stark K et al. (2006). "Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1". Biochem. Biophys. Res. Commun. 341 (2): 451–8. doi:10.1016/j.bbrc.2005.12.200. PMID 16426568.
- Gomez A, Karlgren M, Edler D et al. (2007). "Expression of CYP2W1 in colon tumors: regulation by gene methylation". Pharmacogenomics 8 (10): 1315–25. doi:10.2217/14622416.8.10.1315. PMID 17979506.
- Nelson DR, Zeldin DC, Hoffman SM et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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