CYP2U1
| Cytochrome P450, family 2, subfamily U, polypeptide 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CYP2U1 ; P450TEC; SPG49; SPG56 | ||||||||||||
| External IDs | OMIM: 610670 MGI: 1918769 HomoloGene: 77704 IUPHAR: 1335 GeneCards: CYP2U1 Gene | ||||||||||||
| EC number | 1.14.14.1 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 113612 | 71519 | |||||||||||
| Ensembl | ENSG00000155016 | ENSMUSG00000027983 | |||||||||||
| UniProt | Q7Z449 | Q9CX98 | |||||||||||
| RefSeq (mRNA) | NM_183075 | NM_027816 | |||||||||||
| RefSeq (protein) | NP_898898 | NP_082092 | |||||||||||
| Location (UCSC) | Chr 4: 108.85 – 108.87 Mb | Chr 3: 131.29 – 131.3 Mb | |||||||||||
| PubMed search | |||||||||||||
CYP2U1 (cytochrome P450, family 2, subfamily U, polypeptide 1) is a protein that in humans is encoded by the CYP2U1 gene[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.[2] CYP2U1 metabolized arachidonic acid, docosahexaenoic acid (DHA), and other long chain fatty acids which suggests that CYP2U1 may play a role in brain and immune functions.[1] CYP2U1 also metabolizes propanone, acetone, and 2-oxypropane.
References
- ↑ 1.0 1.1 Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B (February 2004). "CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids". J. Biol. Chem. 279 (8): 6305–14. doi:10.1074/jbc.M311830200. PMID 14660610.
- ↑ "Entrez Gene: CYP2U1".
Further reading
- Nelson DR (2004). "'Frankenstein genes', or the Mad Magazine version of the human pseudogenome.". Hum. Genomics 1 (4): 310–6. PMC 3525266. PMID 15588491.
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wistow G, Bernstein SL, Ray S et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
- Nelson DR, Zeldin DC, Hoffman SM et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
- Karlgren M, Backlund M, Johansson I et al. (2004). "Characterization and tissue distribution of a novel human cytochrome P450-CYP2U1". Biochem. Biophys. Res. Commun. 315 (3): 679–85. doi:10.1016/j.bbrc.2004.01.110. PMID 14975754.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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