CYP2C18

Cytochrome P450, family 2, subfamily C, polypeptide 18
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCYP2C18 ; CPCI; CYP2C; CYP2C17; P450-6B/29C; P450IIC17
External IDsOMIM: 601131 MGI: 1919332 HomoloGene: 133567 IUPHAR: 1327 ChEMBL: 2408 GeneCards: CYP2C18 Gene
EC number1.14.14.1
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez156272082
EnsemblENSG00000108242ENSMUSG00000025002
UniProtP33260Q9D816
RefSeq (mRNA)NM_000772NM_028089
RefSeq (protein)NP_000763NP_082365
Location (UCSC)Chr 10:
96.44 – 96.5 Mb		Chr 19:
39.01 – 39.04 Mb
PubMed search

Cytochrome P450 2C18 is a protein that in humans is encoded by the CYP2C18 gene.[1][2][3]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP4217 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19.[3]

References

  1. ↑ Furuya H, Meyer UA, Gelboin HV, Gonzalez FJ (Oct 1991). "Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA". Mol Pharmacol 40 (3): 375–82. PMID 1896026.
  2. ↑ Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA (May 1991). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily". Biochemistry 30 (13): 3247–55. doi:10.1021/bi00227a012. PMID 2009263.
  3. ↑ 3.0 3.1 "Entrez Gene: CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18".

Further reading

  • Goldstein JA, de Morais SM (1995). "Biochemistry and molecular biology of the human CYP2C subfamily". Pharmacogenetics 4 (6): 285–99. doi:10.1097/00008571-199412000-00001. PMID 7704034.
  • Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.
  • Ged C, Beaune P (1993). "Partial sequence and polymerase chain reaction-mediated analysis of expression of the human CYP2C18 gene". Pharmacogenetics 2 (3): 109–15. doi:10.1097/00008571-199206000-00002. PMID 1306110.
  • Romkes M, Faletto MB, Blaisdell JA et al. (1993). "Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily". Biochemistry 32 (5): 1390. doi:10.1021/bi00056a025. PMID 8095407.
  • Goldstein JA, Faletto MB, Romkes-Sparks M et al. (1994). "Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans". Biochemistry 33 (7): 1743–52. doi:10.1021/bi00173a017. PMID 8110777.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • de Morais SM, Schweikl H, Blaisdell J, Goldstein JA (1993). "Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18". Biochem. Biophys. Res. Commun. 194 (1): 194–201. doi:10.1006/bbrc.1993.1803. PMID 8333835.
  • Richardson TH, Griffin KJ, Jung F et al. (1997). "Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51". Arch. Biochem. Biophys. 338 (2): 157–64. doi:10.1006/abbi.1996.9817. PMID 9028867.
  • Zaphiropoulos PG (1997). "Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis". Mol. Cell. Biol. 17 (6): 2985–93. PMC 232150. PMID 9154796.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Macé K, Bowman ED, Vautravers P et al. (1998). "Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues". Eur. J. Cancer 34 (6): 914–20. doi:10.1016/S0959-8049(98)00034-3. PMID 9797707.
  • Klose TS, Blaisdell JA, Goldstein JA (1999). "Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs". J. Biochem. Mol. Toxicol. 13 (6): 289–95. doi:10.1002/(SICI)1099-0461(1999)13:6<289::AID-JBT1>3.0.CO;2-N. PMID 10487415.
  • Finta C, Zaphiropoulos PG (2000). "The human CYP2C locus: a prototype for intergenic and exon repetition splicing events". Genomics 63 (3): 433–8. doi:10.1006/geno.1999.6063. PMID 10704292.
  • Thum T, Borlak J (2000). "Gene expression in distinct regions of the heart". Lancet 355 (9208): 979–83. doi:10.1016/S0140-6736(00)99016-0. PMID 10768437.
  • Marill J, Cresteil T, Lanotte M, Chabot GG (2001). "Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites". Mol. Pharmacol. 58 (6): 1341–8. PMID 11093772.
  • Zhu-Ge J, Yu YN, Qian YL, Li X (2003). "Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing". World J. Gastroenterol. 8 (5): 888–92. PMID 12378636.