CXO
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CXO may refer to:
- Chandra X-ray Observatory, a satellite launched by NASA in 1999
- Chief Experience Officer, corporate officer responsible for the overall user experience of an organization
- CxO (Chief x Officer), a generic term for any Corporate officer
- CrossOver, a commercial version of WINE which runs Windows applications on Linux, Mac OS X and Solaris
- Lone Star Executive Airport, the airport in Conroe, Texas, United States (IATA code)