CXCL7

Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)

PDB rendering based on 1f9p.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsPPBP ; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
External IDsOMIM: 121010 MGI: 1888712 HomoloGene: 136759 GeneCards: PPBP Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez547357349
EnsemblENSG00000163736ENSMUSG00000029372
UniProtP02775Q9EQI5
RefSeq (mRNA)NM_002704NM_023785
RefSeq (protein)NP_002695NP_076274
Location (UCSC)Chr 4:
74.85 – 74.85 Mb		Chr 5:
90.77 – 90.77 Mb
PubMed search

Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.[1]

The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).[2]

It is a protein that is released in large amounts from platelets following their activation.[3] It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.[4][5]

References

  1. ↑ "Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)".
  2. ↑ Hristov M, Zernecke A, Bidzhekov K et al. (March 2007). "Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury". Circ. Res. 100 (4): 590–7. doi:10.1161/01.RES.0000259043.42571.68. PMID 17272812.
  3. ↑ Majumdar S, Gonder D, Koutsis B, Poncz M (1991). "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4". J Biol Chem 266 (9): 5785–9. PMID 1826003.
  4. ↑ Castor C, Miller J, Walz D (1983). "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor". Proc Natl Acad Sci USA 80 (3): 765–9. doi:10.1073/pnas.80.3.765. PMC 393460. PMID 6572368.
  5. ↑ Castor C, Furlong A, Carter-Su C (1985). "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III". Biochemistry 24 (7): 1762–7. doi:10.1021/bi00328a029. PMID 4005226.

Further reading

  • Begg GS, Pepper DS, Chesterman CN, Morgan FJ (1978). "Complete covalent structure of human beta-thromboglobulin.". Biochemistry 17 (9): 1739–44. doi:10.1021/bi00602a024. PMID 77677.
  • Kaplan KL, Broekman MJ, Chernoff A et al. (1979). "Platelet alpha-granule proteins: studies on release and subcellular localization.". Blood 53 (4): 604–18. PMID 426909.
  • Tunnacliffe A, Majumdar S, Yan B, Poncz M (1992). "Genes for beta-thromboglobulin and platelet factor 4 are closely linked and form part of a cluster of related genes on chromosome 4.". Blood 79 (11): 2896–900. PMID 1316786.
  • Cohen AB, Stevens MD, Miller EJ et al. (1992). "Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets.". Am. J. Physiol. 263 (2 Pt 1): L249–56. PMID 1387511.
  • Morris SW, Nelson N, Valentine MB et al. (1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.". Genomics 14 (3): 685–91. doi:10.1016/S0888-7543(05)80169-7. PMID 1427896.
  • Majumdar S, Gonder D, Koutsis B, Poncz M (1991). "Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4.". J. Biol. Chem. 266 (9): 5785–9. PMID 1826003.
  • Wenger RH, Hameister H, Clemetson KJ (1991). "Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12-q13 along with other genes of the beta-thromboglobulin superfamily.". Hum. Genet. 87 (3): 367–8. doi:10.1007/BF00200921. PMID 1830861.
  • Hjemdahl P, Perneby C, Theodorsson E et al. (1992). "A new assay for beta-thromboglobulin in urine.". Thromb. Res. 64 (1): 33–43. doi:10.1016/0049-3848(91)90203-9. PMID 1837963.
  • Brandt E, Van Damme J, Flad HD (1991). "Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III.". Cytokine 3 (4): 311–21. doi:10.1016/1043-4666(91)90499-4. PMID 1873479.
  • Clark-Lewis I, Moser B, Walz A et al. (1991). "Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide.". Biochemistry 30 (12): 3128–35. doi:10.1021/bi00226a021. PMID 2007144.
  • Walz A, Baggiolini M (1990). "Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.". J. Exp. Med. 171 (2): 449–54. doi:10.1084/jem.171.2.449. PMC 2187709. PMID 2406364.
  • Holt JC, Harris ME, Holt AM et al. (1986). "Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin.". Biochemistry 25 (8): 1988–96. doi:10.1021/bi00356a023. PMID 2423119.
  • Walz A, Baggiolini M (1989). "A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils.". Biochem. Biophys. Res. Commun. 159 (3): 969–75. doi:10.1016/0006-291X(89)92203-1. PMID 2522778.
  • Wenger RH, Wicki AN, Walz A et al. (1989). "Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library.". Blood 73 (6): 1498–503. PMID 2713489.
  • Castor CW, Walz DA, Ragsdale CG et al. (1989). "Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets.". Biochem. Biophys. Res. Commun. 163 (2): 1071–8. doi:10.1016/0006-291X(89)92330-9. PMID 2783111.
  • Holt JC, Rabellino EM, Gewirtz AM et al. (1988). "Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human platelets and megakaryocytes.". Exp. Hematol. 16 (4): 302–6. PMID 2966071.
  • Castor CW, Furlong AM, Carter-Su C (1985). "Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III.". Biochemistry 24 (7): 1762–7. doi:10.1021/bi00328a029. PMID 4005226.
  • McLaren KM, Pepper DS (1983). "Immunological localisation of beta-thromboglobulin and platelet factor 4 in human megakaryocytes and platelets.". J. Clin. Pathol. 35 (11): 1227–31. doi:10.1136/jcp.35.11.1227. PMC 497932. PMID 6183294.
  • Castor CW, Miller JW, Walz DA (1983). "Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.". Proc. Natl. Acad. Sci. U.S.A. 80 (3): 765–9. doi:10.1073/pnas.80.3.765. PMC 393460. PMID 6572368.
  • Malkowski MG, Wu JY, Lazar JB et al. (1995). "The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution.". J. Biol. Chem. 270 (13): 7077–87. doi:10.1074/jbc.270.13.7077. PMID 7706245.