CXCL15

Interleukin 8
Identifiers
SymbolsIl8 ; Cxcl15; Scyb15; lungkine; weche
External IDsMGI: 1339941 GeneCards: Il8 Gene
Orthologs
SpeciesHumanMouse
Entrez2030920309
EnsemblENSMUSG00000029375ENSMUSG00000029375
UniProtQ9WVL7Q9WVL7
RefSeq (mRNA)NM_011339NM_011339
RefSeq (protein)NP_035469NP_035469
Location (UCSC)Chr 5:
90.79 – 90.8 Mb		Chr 5:
91.22 – 91.23 Mb
PubMed search

Chemokine (C-X-C motif) ligand 15 (CXCL15) is a small cytokine belonging to the CXC chemokine family that has been described in the mouse. This chemokine is also known under the name lungkine. CXCL15 is an ELR+ CXC chemokine (it contains the amino acid sequence E-L-R immediately before its CXC motif) that recruits neutrophils during inflammation of the lungs. It is highly abundant in epithelial cells of the lung,[1] and can also be found in other mucosal organs such as the urogenital and gastrointestinal tracts, and in endocrine organs like the adrenal gland.[2] The gene for CXCL15 is found on mouse chromosome 5.

References

  1. ↑ Rossi D, Hurst S, Xu Y, Wang W, Menon S, Coffman R, Zlotnik A (1999). "Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells". J Immunol 162 (9): 5490–7. PMID 10228029.
  2. ↑ Schmitz J, McCracken V, Dimmitt R, Lorenz R (2007). "Expression of CXCL15 (Lungkine) in Murine Gastrointestinal, Urogenital, and Endocrine Organs". J Histochem Cytochem 55 (5): 515–24. doi:10.1369/jhc.6A7121.2007. PMID 17242461.