CTTNBP2
| Cortactin binding protein 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CTTNBP2 ; C7orf8; CORTBP2; Orf4 | ||||||||||||
| External IDs | OMIM: 609772 MGI: 1353467 HomoloGene: 14125 GeneCards: CTTNBP2 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 83992 | 30785 | |||||||||||
| Ensembl | ENSG00000077063 | ENSMUSG00000000416 | |||||||||||
| UniProt | Q8WZ74 | B9EJA2 | |||||||||||
| RefSeq (mRNA) | NM_033427 | NM_080285 | |||||||||||
| RefSeq (protein) | NP_219499 | NP_525024 | |||||||||||
| Location (UCSC) | Chr 7: 117.35 – 117.51 Mb | Chr 6: 18.37 – 18.51 Mb | |||||||||||
| PubMed search | |||||||||||||
Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene.[1][2]
Function
This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.[2]
Interactions
CTTNBP2 has been shown to interact with:
References
- ↑ Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (Nov 2001). "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31". Genomics 78 (1-2): 7–11. doi:10.1006/geno.2001.6651. PMID 11707066.
- ↑ 2.0 2.1 "Entrez Gene: CTTNBP2 cortactin binding protein 2".
- ↑ 3.0 3.1 3.2 3.3 3.4 Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A et al. (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
Further reading
- Ohoka Y, Takai Y (1998). "Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90". Genes Cells 3 (9): 603–12. doi:10.1046/j.1365-2443.1998.00216.x. PMID 9813110.
- Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
- Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C et al. (2004). "Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei". J. Cell Biol. 166 (6): 815–25. doi:10.1083/jcb.200404107. PMC 2172106. PMID 15364959.