CRTC3

CREB regulated transcription coactivator 3
Identifiers
SymbolsCRTC3 ; TORC-3; TORC3
External IDsOMIM: 608986 MGI: 1917711 HomoloGene: 11248 GeneCards: CRTC3 Gene
Orthologs
SpeciesHumanMouse
Entrez6478470461
EnsemblENSG00000140577ENSMUSG00000030527
UniProtQ6UUV7Q91X84
RefSeq (mRNA)NM_001042574NM_173863
RefSeq (protein)NP_001036039NP_776288
Location (UCSC)Chr 15:
91.07 – 91.19 Mb		Chr 7:
80.59 – 80.69 Mb
PubMed search

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene.[1][2][3]

This gene has been shown to be linked to weight gain.[4]

References

  1. ↑ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB et al. (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
  2. ↑ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM et al. (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
  3. ↑ "Entrez Gene: CRTC3 CREB regulated transcription coactivator 3".
  4. ↑ Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R et al. (Dec 2010). "CRTC3 links catecholamine signalling to energy balance". Nature 468 (7326): 933–939. doi:10.1038/nature09564. PMID 21164481.

Further reading

  • Hishiki T, Ohshima T, Ego T, Shimotohno K (Sep 2007). "BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3". The Journal of Biological Chemistry 282 (39): 28335–43. doi:10.1074/jbc.M702656200. PMID 17644518.
  • Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS et al. (Sep 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America 103 (39): 14379–84. doi:10.1073/pnas.0606714103. PMC 1569674. PMID 16980408.
  • Koga H, Ohshima T, Shimotohno K (Dec 2004). "Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3". The Journal of Biological Chemistry 279 (51): 52978–83. doi:10.1074/jbc.M409021200. PMID 15466468. Check date values in: |year= / |date= mismatch (help)
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S et al. (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology : CB 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links