CRTC2
| CREB regulated transcription coactivator 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CRTC2 ; TORC-2; TORC2 | ||||||||||||
| External IDs | OMIM: 608972 MGI: 1921593 HomoloGene: 18765 GeneCards: CRTC2 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 200186 | 74343 | |||||||||||
| Ensembl | ENSG00000160741 | ENSMUSG00000027936 | |||||||||||
| UniProt | Q53ET0 | Q3U182 | |||||||||||
| RefSeq (mRNA) | NM_181715 | NM_028881 | |||||||||||
| RefSeq (protein) | NP_859066 | NP_083157 | |||||||||||
| Location (UCSC) | Chr 1: 153.92 – 153.93 Mb | Chr 3: 90.25 – 90.26 Mb | |||||||||||
| PubMed search | |||||||||||||
CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.[1][2][3]
Function
CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.[4]
Interactions
CRTC2 has been shown to interact with SNF1LK2[5] and YWHAQ.[5][6]
References
- ↑ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2".
- ↑ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
- ↑ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Mol. Cell 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
- ↑ Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". Bioessays 28 (3): 231–4. doi:10.1002/bies.20375. PMID 16479585.
- ↑ 5.0 5.1 Screaton, Robert A; Conkright Michael D, Katoh Yoshiko, Best Jennifer L, Canettieri Gianluca, Jeffries Shawn, Guzman Ernesto, Niessen Sherry, Yates John R, Takemori Hiroshi, Okamoto Mitsuhiro, Montminy Marc (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell (United States) 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. ISSN 0092-8674. PMID 15454081.
- ↑ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Iourgenko V, Zhang W, Mickanin C et al. (2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
- Conkright MD, Canettieri G, Screaton R et al. (2003). "TORCs: transducers of regulated CREB activity.". Mol. Cell 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Jin J, Smith FD, Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Screaton RA, Conkright MD, Katoh Y et al. (2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.". Cell 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
- Al-Hakim AK, Göransson O, Deak M et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.". J. Cell. Sci. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228.
- Siu YT, Chin KT, Siu KL et al. (2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats.". J. Virol. 80 (14): 7052–9. doi:10.1128/JVI.00103-06. PMC 1489057. PMID 16809310.
- Wu Z, Huang X, Feng Y et al. (2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.". Proc. Natl. Acad. Sci. U.S.A. 103 (39): 14379–84. doi:10.1073/pnas.0606714103. PMC 1569674. PMID 16980408.
- Yang Q, Inoki K, Ikenoue T, Guan KL (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.". Genes Dev. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC 1619946. PMID 17043309.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Ravnskjaer K, Kester H, Liu Y et al. (2007). "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression.". EMBO J. 26 (12): 2880–9. doi:10.1038/sj.emboj.7601715. PMC 1894761. PMID 17476304.
- Kuraishy AI, French SW, Sherman M et al. (2007). "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation.". Proc. Natl. Acad. Sci. U.S.A. 104 (24): 10175–80. doi:10.1073/pnas.0704170104. PMC 1891214. PMID 17548807.
External links
- CRTC2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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