CREB1

CAMP responsive element binding protein 1
PDB rendering based on 1dh3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2LXT
Identifiers
Symbols	CREB1 ; CREB
External IDs	OMIM: 123810 MGI: 88494 HomoloGene: 3223 ChEMBL: 5587 GeneCards: CREB1 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • RNA polymerase II activating transcription factor binding • RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription • sequence-specific DNA binding transcription factor activity • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity • transcription cofactor activity • protein binding • enzyme binding • cAMP response element binding Cellular component • nucleus • nucleoplasm • transcription factor complex • nuclear euchromatin • nucleolus Biological process • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • transcription from RNA polymerase II promoter • protein phosphorylation • signal transduction • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • Notch signaling pathway • synaptic transmission • axon guidance • lactation • circadian rhythm • regulation of cell size • fibroblast growth factor receptor signaling pathway • response to organic substance • negative regulation of transcription by competitive promoter binding • viral process • pituitary gland development • secretory granule organization • response to glucagon • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 5 signaling pathway • toll-like receptor 9 signaling pathway • toll-like receptor 10 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • positive regulation of multicellular organism growth • response to drug • innate immune response • positive regulation of fat cell differentiation • positive regulation of osteoclast differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of hormone secretion • positive regulation of lipid biosynthetic process • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • protein stabilization • stress-activated MAPK cascade • lung saccule development • Type I pneumocyte differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1385	12912
Ensembl	ENSG00000118260	ENSMUSG00000025958
UniProt	P16220	Q01147
RefSeq (mRNA)	NM_004379	NM_001037726
RefSeq (protein)	NP_004370	NP_001032815
Location (UCSC)	Chr 2: 208.39 – 208.47 Mb	Chr 1: 64.53 – 64.6 Mb
PubMed search

CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene.^[1][2] This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[3]

See also

• CREB

Interactions

CREB1 has been shown to interact with:

• CEBPB ,^[4]
• CREB binding protein ,^{[5][6][7][8][9][10][11][12][13][14]}
• FHL2 ,^[15]
• FHL3 ,^[15]
• FHL5 .^[15]
• HTATIP ,^[16]
• P53 ,^[11] and
• RPS6KA5 .^[17][18]

References

Further reading

External links

• CREB1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

PDB gallery 1dh3: CRYSTAL STRUCTURE OF A CREB BZIP-CRE COMPLEX REVEALS THE BASIS FOR CREB FAIMLY SELECTIVE DIMERIZATION AND DNA BINDING