CRADD
Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.[1][2][3]
Function
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.[3]
Interactions
CRADD has been shown to interact with RIPK1[1][2] and Caspase 2.[1][4][5]
References
- ↑ 1.0 1.1 1.2 Duan H, Dixit VM (January 1997). "RAIDD is a new 'death' adaptor molecule". Nature 385 (6611): 86–9. doi:10.1038/385086a0. PMID 8985253.
- ↑ 2.0 2.1 Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T et al. (March 1997). "CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP". Cancer Res. 57 (4): 615–9. PMID 9044836.
- ↑ 3.0 3.1 "Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain".
- ↑ Tinel A, Tschopp J (May 2004). "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress". Science 304 (5672): 843–6. doi:10.1126/science.1095432. PMID 15073321.
- ↑ Droin N, Beauchemin M, Solary E, Bertrand R (December 2000). "Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade". Cancer Res. 60 (24): 7039–47. PMID 11156409.
Further reading
- Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression". Genomics 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.
- Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S et al. (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Chou JJ, Matsuo H, Duan H, Wagner G (1998). "Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment". Cell 94 (2): 171–80. doi:10.1016/S0092-8674(00)81417-8. PMID 9695946.
- Horvat S, Medrano JF (1998). "A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region". Genomics 54 (1): 159–64. doi:10.1006/geno.1998.5540. PMID 9806843.
- Shearwin-Whyatt LM, Harvey NL, Kumar S (2000). "Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD". Cell Death Differ. 7 (2): 155–65. doi:10.1038/sj.cdd.4400632. PMID 10713730.
- Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L (2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene 19 (39): 4451–60. doi:10.1038/sj.onc.1203812. PMID 11002417.
- Droin N, Beauchemin M, Solary E, Bertrand R (2000). "Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade". Cancer Res. 60 (24): 7039–47. PMID 11156409.
- Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES (2002). "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria". J. Biol. Chem. 277 (16): 13430–7. doi:10.1074/jbc.M108029200. PMID 11832478.
- Tinel A, Tschopp J (2004). "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress". Science 304 (5672): 843–6. doi:10.1126/science.1095432. PMID 15073321.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Park HH, Wu H (2006). "Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly". J. Mol. Biol. 357 (2): 358–64. doi:10.1016/j.jmb.2005.12.082. PMC 2902980. PMID 16434054.
- Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B (2006). "Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage". Oncogene 25 (41): 5683–92. doi:10.1038/sj.onc.1209569. PMID 16652156.
- Park HH, Wu H (2007). "Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (Pt 3): 229–32. doi:10.1107/S1744309107007889. PMC 2330181. PMID 17329820.
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