CPNE8
| Copine VIII | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | CPNE8 ; MGC129645; MGC129646 | ||||||||
| External IDs | MGI: 1914121 HomoloGene: 12049 GeneCards: CPNE8 Gene | ||||||||
| |||||||||
| Orthologs | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | 144402 | 66871 | |||||||
| Ensembl | ENSG00000139117 | ENSMUSG00000052560 | |||||||
| UniProt | Q86YQ8 | Q9DC53 | |||||||
| RefSeq (mRNA) | NM_153634 | NM_001033851 | |||||||
| RefSeq (protein) | NP_705898 | NP_001029023 | |||||||
| Location (UCSC) | Chr 12: 39.04 – 39.3 Mb | Chr 15: 90.49 – 90.68 Mb | |||||||
| PubMed search | |||||||||
Copine-8 is a protein that in humans is encoded by the CPNE8 gene.[1][2]
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus.[2]
References
- ↑ Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B (Apr 2003). "Cloning, molecular characterization, and expression analysis of Copine 8". Biochem Biophys Res Commun 303 (3): 842–847. doi:10.1016/S0006-291X(03)00445-5. PMID 12670487.
- ↑ 2.0 2.1 "Entrez Gene: CPNE8 copine VIII".
Further reading
- Creutz CE; Tomsig JL; Snyder SL et al. (1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J. Biol. Chem. 273 (3): 1393–1402. doi:10.1074/jbc.273.3.1393. PMID 9430674.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Tomsig JL, Creutz CE (2001). "Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein". Biochemistry 39 (51): 16163–16175. doi:10.1021/bi0019949. PMID 11123945.
- Wiemann S; Weil B; Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ramsey H; Zhang DE; Richkind K et al. (2003). "Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation". Leukemia 17 (8): 1665–1666. doi:10.1038/sj.leu.2403048. PMID 12886257.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S; Arlt D; Huber W et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Mehrle A; Rosenfelder H; Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.