COX8A

Cytochrome c oxidase subunit VIIIA (ubiquitous)
Identifiers
SymbolsCOX8A ; COX; COX8; COX8-2; COX8L; VIII; VIII-L
External IDsOMIM: 123870 HomoloGene: 3006 GeneCards: COX8A Gene
EC number1.9.3.1
Orthologs
SpeciesHumanMouse
Entrez135112868
EnsemblENSG00000176340ENSMUSG00000035885
UniProtP10176Q64445
RefSeq (mRNA)NM_004074NM_007750
RefSeq (protein)NP_004065NP_031776
Location (UCSC)Chr 11:
63.97 – 63.98 Mb		Chr 19:
7.22 – 7.22 Mb
PubMed search

Cytochrome c oxidase subunit 8A is a protein that in humans is encoded by the COX8A gene.[1] Cytochrome c oxidase 8A is a subunit of the cytochrome c oxidase complex, also known as Complex IV.

Structure

COX8A is a 7.6 kDa protein composed of 69 amino acids.[2][3] This gene encodes the nuclear-encoded subunit 8A of the human mitochondrial respiratory chain enzyme complex cytochrome c oxidase. The complex consists of 13 mitochondrial- and nuclear-encoded subunits.[1]

Function

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex.[1]

References

  1. ↑ 1.0 1.1 1.2 "Entrez Gene: Cytochrome c oxidase subunit VIIIA (ubiquitous)".
  2. ↑ Zong N, Li H, Li H, Lam M, Jimenez R, Kim C et al. (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
  3. ↑ "Cytochrome c oxidase subunit 8A". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.