CORO1A

Coronin, actin binding protein, 1A

PDB rendering based on 2aq5.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCORO1A ; CLABP; CLIPINA; HCORO1; IMD8; TACO; p57
External IDsOMIM: 605000 MGI: 1345961 HomoloGene: 6545 GeneCards: CORO1A Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1115112721
EnsemblENSG00000102879ENSMUSG00000030707
UniProtP31146O89053
RefSeq (mRNA)NM_001193333NM_009898
RefSeq (protein)NP_001180262NP_034028
Location (UCSC)Chr 16:
30.19 – 30.2 Mb
Chr 7:
126.7 – 126.71 Mb
PubMed search

Coronin-1A is a protein that in humans is encoded by the CORO1A gene.[1][2] It has been implicated in both T-cell mediated immunity and mitochondrial apoptosis. In a recent genome-wide longevity study, its expression levels were found to be negatively associated both with age at the time of blood sample and the survival time after blood draw.[3]

References

  1. Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (Oct 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID 9778037.
  2. "Entrez Gene: CORO1A coronin, actin binding protein, 1A".
  3. Kerber RA, O'Brien E, Cawthon RM. (2009). "Gene Expression Profiles Associated with Aging and Mortality in Humans.". Aging Cell.: 1–20. doi:10.1111/j.1474-9726.2009.00467.

Further reading