CORIN

Corin, serine peptidase

Identifiers

CORIN ; ATC2; CRN; Lrp4; PEE5; TMPRSS10

External IDs

OMIM: 605236 MGI: 1349451 HomoloGene: 4804 GeneCards: CORIN Gene

Gene ontology
Molecular function	• serine-type endopeptidase activity • serine-type exopeptidase activity
Cellular component	• extracellular region • plasma membrane • integral component of plasma membrane • cell surface • integral component of membrane
Biological process	• regulation of systemic arterial blood pressure by atrial natriuretic peptide • proteolysis • female pregnancy • regulation of blood pressure • peptide hormone processing • regulation of renal sodium excretion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000145244

ENSMUSG00000005220

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
47.6 – 47.84 Mb

Chr 5:
72.3 – 72.5 Mb

PubMed search

Not to be confused with Lipoprotein receptor-related protein 4, which is also abbreviated as LRP4.

Atrial natriuretic peptide-converting enzyme is a protein that in humans is encoded by the CORIN gene.^[1]^[2]

This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.^[2]

References

↑ Yan W, Sheng N, Seto M, Morser J, Wu Q (Jul 1999). "Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart". J Biol Chem 274 (21): 14926–35. doi:10.1074/jbc.274.21.14926. PMID 10329693.
↑ 2.0 2.1 "Entrez Gene: CORIN corin, serine peptidase".

Further reading

Yan W, Wu F, Morser J, Wu Q (2000). "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8525–9. doi:10.1073/pnas.150149097. PMC 26981. PMID 10880574.
Hooper JD, Scarman AL, Clarke BE et al. (2001). "Localization of the mosaic transmembrane serine protease corin to heart myocytes". Eur. J. Biochem. 267 (23): 6931–7. doi:10.1046/j.1432-1033.2000.01806.x. PMID 11082206.
Wu F, Yan W, Pan J et al. (2002). "Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes". J. Biol. Chem. 277 (19): 16900–5. doi:10.1074/jbc.M201503200. PMID 11884416.
Pan J, Hinzmann B, Yan W et al. (2002). "Genomic structures of the human and murine corin genes and functional GATA elements in their promoters". J. Biol. Chem. 277 (41): 38390–8. doi:10.1074/jbc.M205686200. PMID 12154094.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Knappe S, Wu F, Masikat MR et al. (2004). "Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin". J. Biol. Chem. 278 (52): 52363–70. doi:10.1074/jbc.M309991200. PMID 14559895.
Knappe S, Wu F, Madlansacay MR, Wu Q (2004). "Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide". J. Biol. Chem. 279 (33): 34464–71. doi:10.1074/jbc.M405041200. PMID 15192093.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dries DL, Victor RG, Rame JE et al. (2006). "Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension". Circulation 112 (16): 2403–10. doi:10.1161/CIRCULATIONAHA.105.568881. PMID 16216958.
Rame JE, Drazner MH, Post W et al. (2007). "Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload". Hypertension 49 (4): 857–64. doi:10.1161/01.HYP.0000258566.95867.9e. PMID 17296875.
Liao X, Wang W, Chen S, Wu Q (2007). "Role of glycosylation in corin zymogen activation". J. Biol. Chem. 282 (38): 27728–35. doi:10.1074/jbc.M703687200. PMID 17660514.
Peleg A, Jaffe AS, Hasin Y (2009). "Enzyme-linked immunoabsorbent assay for detection of human serine protease corin in blood". Clin Chim Acta 409 (1): 85–9. doi:10.1016/j.cca.2009.09.004. PMID 19751717.