COPS7A

COP9 signalosome subunit 7A

Identifiers

COPS7A ; CSN7A; SGN7a

External IDs

MGI: 1349400 HomoloGene: 22685 GeneCards: COPS7A Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• cytoplasm • COP9 signalosome
Biological process	• cullin deneddylation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000111652

ENSMUSG00000030127

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
6.83 – 6.84 Mb

Chr 6:
124.96 – 124.97 Mb

PubMed search

COP9 signalosome complex subunit 7a is a protein that in humans is encoded by the COPS7A gene.^[1]

References

↑ "Entrez Gene: COPS7A COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)".

Further reading

Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295.
Seeger M; Kraft R; Ferrell K et al. (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219.
Wei N; Tsuge T; Serino G et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402.
Bech-Otschir D; Kraft R; Huang X et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC 145508. PMID 11285227.
Lyapina S; Cope G; Shevchenko A et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.
Wang Y, Devereux W, Stewart TM, Casero RA (2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". Biochem. J. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMC 1222765. PMID 12020345.
Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Serino G; Su H; Peng Z et al. (2003). "Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex". Plant Cell 15 (3): 719–31. doi:10.1105/tpc.009092. PMC 150025. PMID 12615944.
Uhle S; Medalia O; Waldron R et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC 151059. PMID 12628923.
Groisman R; Polanowska J; Kuraoka I et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell 113 (3): 357–67. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Obuse C; Iwasaki O; Kiyomitsu T et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
Stelzl U; Worm U; Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.