COG4

Component of oligomeric golgi complex 4
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCOG4 ; CDG2J; COD1
External IDsOMIM: 606976 MGI: 2142808 HomoloGene: 7155 GeneCards: COG4 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez25839102339
EnsemblENSG00000103051ENSMUSG00000031753
UniProtQ9H9E3Q8R1U1
RefSeq (mRNA)NM_001195139NM_133973
RefSeq (protein)NP_001182068NP_598734
Location (UCSC)Chr 16:
70.51 – 70.56 Mb
Chr 8:
110.85 – 110.88 Mb
PubMed search

Conserved oligomeric Golgi complex subunit 4 is a protein that in humans is encoded by the COG4 gene.[1][2]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4 (Ungar et al., 2002).[supplied by OMIM][2]

Interactions

COG4 has been shown to interact with COG7,[3] COG2,[3] COG1[3] and COG5.[3]

References

  1. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
  2. 2.0 2.1 "Entrez Gene: COG4 component of oligomeric golgi complex 4".
  3. 3.0 3.1 3.2 3.3 Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. (United States) 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.

Further reading

External links