CNTROB

Centrobin, centrosomal BRCA2 interacting protein

Identifiers

External IDs

OMIM: 611425 MGI: 2443290 HomoloGene: 14205 GeneCards: CNTROB Gene

Gene ontology
Molecular function	• protein binding • protein domain specific binding
Cellular component	• cytoplasm • centrosome • centriole
Biological process	• cytokinesis • centriole replication • centrosome separation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
7.84 – 7.85 Mb

Chr 11:
69.3 – 69.32 Mb

PubMed search

Centrobin is a protein that in humans is encoded by the CNTROB gene.^[1] It is a centriole-associated protein that asymmetrically localizes to the daughter centriole, and is required for centriole duplication and cytokinesis.^[2]

References

↑ Tchernev, V. T.; Mansfield, T. A.; Giot, L.; Kumar, A. M.; Nandabalan, K.; Li, Y.; Mishra, V. S.; Detter, J. C.; Rothberg, J. M.; Wallace, M. R.; Southwick, F. S.; Kingsmore, S. F. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular medicine (Cambridge, Mass.) 8 (1): 56–64. PMC 2039936. PMID 11984006.
↑ Zou, C.; Li, J.; Bai, Y.; Gunning, W.; Wazer, D.; Band, V.; Gao, Q. (2005). "Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication". Journal of Cell Biology 171 (3): 437–445. doi:10.1083/jcb.200506185. PMC 2171251. PMID 16275750.

Jeong Y, Lee J, Kim K et al. (2007). "Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization.". J. Cell. Sci. 120 (Pt 12): 2106–16. doi:10.1242/jcs.03458. PMID 17535851.
Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Wan D, Gong Y, Qin W et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

The centrosome and its components

Centrioles

SASS6
CENPJ
CNTROB
CEP104
Centrins (CETN1, CETN2 and CETN3)
SFI1

Pericentriolar material

other proteins

Index of cells

Description	Structure nucleus chromosome genetics Organelles peroxisome cytoskeleton centrosome epithelia cilia mitochondria Membranes proteins cell adhesions Membrane transport ion channels vesicular transport solute carrier ABC transporters ATPase oxidoreduction-driven

Disease	Structural peroxisome cytoskeleton cilia mitochondria nucleus scleroprotein Membrane channelopathy solute carrier ATPase ABC transporters other extracellular ligands cell surface receptors intracellular signalling Vesicular transport Pore-forming toxins

CNTROB

References

Further reading