CNOT4
Template:PBB/4850
CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene. [1]
Function
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010].
References
- ↑ "Entrez Gene: CCR4-NOT transcription complex, subunit 4". Retrieved 2013-10-29.
Further reading
- Gronholm, J.; Kaustio, M.; Myllymaki, H.; Kallio, J.; Saarikettu, J.; Kronhamn, J.; Valanne, S.; Silvennoinen, O.; Ramet, M. (2011). "Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells". The FASEB Journal 26 (3): 1239–1250. doi:10.1096/fj.11-195875. PMID 22159038.
- Winkler, G. S.; Albert, T. K.; Dominguez, C.; Legtenberg, Y. I. A.; Boelens, R.; Timmers, H. T. M. (2004). "An Altered-specificity Ubiquitin-conjugating Enzyme/Ubiquitin–Protein Ligase Pair". Journal of Molecular Biology 337 (1): 157–165. doi:10.1016/j.jmb.2004.01.031. PMID 15001359.
- Lau, N. C.; Kolkman, A.; Van Schaik, F. M. A.; Mulder, K. W.; Pijnappel, W. W. M. P.; Heck, A. J. R.; Timmers, H. T. M. (2009). "Human Ccr4–Not complexes contain variable deadenylase subunits". Biochemical Journal 422 (3): 443–453. doi:10.1042/BJ20090500. PMID 19558367.
- Albert, T. K.; Hanzawa, H.; Legtenberg, Y. I.; De Ruwe, M. J.; Van Den Heuvel, F. A.; Collart, M. A.; Boelens, R.; Timmers, H. T. (2002). "Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex". The EMBO Journal 21 (3): 355–364. doi:10.1093/emboj/21.3.355. PMC 125831. PMID 11823428.
- Dominguez, C.; Bonvin, A. M. J. J.; Winkler, G. S.; Van Schaik, F. M. A.; Timmers, H. T. M.; Boelens, R. (2004). "Structural Model of the UbcH5B/CNOT4 Complex Revealed by Combining NMR, Mutagenesis, and Docking Approaches". Structure 12 (4): 633–644. doi:10.1016/j.str.2004.03.004. PMID 15062086.
- Wistow, G.; Bernstein, S. L.; Wyatt, M. K.; Fariss, R. N.; Behal, A.; Touchman, J. W.; Bouffard, G.; Smith, D.; Peterson, K. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: Over 6000 non-redundant transcripts, novel genes and splice variants". Molecular vision 8: 205–220. PMID 12107410.
- Mersman, D. P.; Du, H. -N.; Fingerman, I. M.; South, P. F.; Briggs, S. D. (2009). "Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression". Genes & Development 23 (8): 951–962. doi:10.1101/gad.1769209. PMC 2675863. PMID 19346402.
- Hanzawa, H.; De Ruwe, M. J.; Albert, T. K.; Van Der Vliet, P. C.; Timmers, H. T.; Boelens, R. (2000). "The Structure of the C4C4 RING Finger of Human NOT4 Reveals Features Distinct from Those of C3HC4 RING Fingers". Journal of Biological Chemistry 276 (13): 10185–10190. doi:10.1074/jbc.M009298200. PMID 11087754.
- Albert, T. K.; Lemaire, M.; Van Berkum, N. L.; Gentz, R.; Collart, M. A.; Timmers, H. T. (2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic acids research 28 (3): 809–817. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.